NICE DSU Technical Support Document 18: Methods for population-adjusted indirect comparisons in submissions to NICE

Research output: Book/ReportBook



Publication details

DatePublished - 1 Dec 2016
PublisherNICE Decision Support Unit
Original languageEnglish

Publication series

NameTechnical Support Documents
PublisherNICE Decision Support Unit


This Technical Support Document examines methods for population-adjusted indirect comparisons, in which individual patient data (IPD) in one or more trials are used to adjust for between-trial differences in the distribution of variables that influence outcome. Recently proposed methods are the Matching-Adjusted Indirect Comparison (MAIC) and the Simulated Treatment Comparison (STC). We look at the theory behind MAIC and STC methods, review published applications, briefly touch on alternative methods, and make recommendations on the use of population-adjusted estimates in submissions to NICE.

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