By the same authors

From the same journal

Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche

Research output: Contribution to journalArticlepeer-review


  • Marielle Balzano
  • Maria De Grandis
  • Thien-Phong Vu Manh
  • Lionel Chasson
  • Florence Bardin
  • Anne Farina
  • Arnauld Serge
  • Ghislain Bidaut
  • Pierre Charbord
  • Leonard Herault
  • Anne-Laure Bailly
  • Amandine Cartier-Michaud
  • Annie Boned
  • Marc Dalod
  • Estelle Duprez
  • Marc Bajenoff
  • Luc Xerri
  • Michel Aurrand-Lions
  • Claudine Schiff
  • Stephane J.C. Mancini


Publication details

JournalCell reports
DateAccepted/In press - 15 Feb 2019
DatePublished (current) - 19 Mar 2019
Number of pages24
Pages (from-to)3257–3271
Original languageEnglish


In the bone marrow, CXCL12 and IL-7 are essential for B cell differentiation, whereas hematopoietic stem cell (HSC) maintenance requires SCF and CXCL12. Peri-sinusoidal stromal (PSS) cells are the main source of IL-7, but their characterization as a pro-B cell niche remains limited. Here, we characterize pro-B cell supporting stromal cells and decipher the interaction network allowing pro-B cell retention. Preferential contacts are found between pro-B cells and PSS cells, which homogeneously express HSC and B cell niche genes. Furthermore, pro-B cells are frequently located in the vicinity of HSCs in the same niche. Using an interactome bioinformatics pipeline, we identify Nidogen-1 as essential for pro-B cell retention in the peri-sinusoidal niche as confirmed in Nidogen-1−/− mice. Finally, human pro-B cells and hematopoietic progenitors are observed close to similar IL-7+ stromal cells. Thus, a multispecific niche exists in mouse and human supporting both early progenitors and committed hematopoietic lineages.

Bibliographical note

© 2019 The Author(s).

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