N,N-Dimethyl Formamide European Restriction Demands Solvent Substitution in Research and Development

James Sherwood, Fernando Albericio, Beatriz G de la Torre

Research output: Contribution to journalReview articlepeer-review


As of December 2023, the use of common solvent N,N-dimethyl formamide (DMF) will be restricted in the European Union because of its reproductive health hazard. Industrial facilities must comply with stricter exposure limits, and researchers are recommended to find alternative solvents. Here we explain the restrictions on DMF, which disciplines are affected, and how to substitute DMF to keep research and development commercially relevant.

Original languageEnglish
Article numbere202301639
Number of pages7
Publication statusE-pub ahead of print - 10 Jan 2024

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© 2024 The Authors.

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