Non-coding RNA production by RNA polymerase III is implicated in cancer

TY - JOUR

T1 - Non-coding RNA production by RNA polymerase III is implicated in cancer

AU - Marshall, L.

AU - White, R.J.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - RNA polymerase III (Pol III) makes a variety of small non-coding RNAs, such as tRNA and 5S ribosomal RNA. Increased expression of pol III products is often observed in transformed cells. Much progress has been made in determining how Pol III-dependent transcription is regulated and how it increases in cancers, but the importance of this increase has not been clearly established. New evidence suggests that Pol III output can substantially affect transformation.

AB - RNA polymerase III (Pol III) makes a variety of small non-coding RNAs, such as tRNA and 5S ribosomal RNA. Increased expression of pol III products is often observed in transformed cells. Much progress has been made in determining how Pol III-dependent transcription is regulated and how it increases in cancers, but the importance of this increase has not been clearly established. New evidence suggests that Pol III output can substantially affect transformation.

UR - http://www.scopus.com/inward/record.url?scp=56749170666&partnerID=8YFLogxK

U2 - 10.1038/nrc2539

DO - 10.1038/nrc2539

M3 - Article

AN - SCOPUS:56749170666

SN - 1474-175X

VL - 8

SP - 911

EP - 914

JO - Nature reviews cancer

JF - Nature reviews cancer

IS - 12

ER -