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Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments

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Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments. / Packer, J R; Hirst, A M; Droop, A P; Adamson, R; Simms, M S; Mann, V M; Frame, F M; O'Connell, D; Maitland, N J.

In: FEBS Letters, 17.09.2019.

Research output: Contribution to journalArticle

Harvard

Packer, JR, Hirst, AM, Droop, AP, Adamson, R, Simms, MS, Mann, VM, Frame, FM, O'Connell, D & Maitland, NJ 2019, 'Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments', FEBS Letters. https://doi.org/10.1002/1873-3468.13589

APA

Packer, J. R., Hirst, A. M., Droop, A. P., Adamson, R., Simms, M. S., Mann, V. M., ... Maitland, N. J. (2019). Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments. FEBS Letters. https://doi.org/10.1002/1873-3468.13589

Vancouver

Packer JR, Hirst AM, Droop AP, Adamson R, Simms MS, Mann VM et al. Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments. FEBS Letters. 2019 Sep 17. https://doi.org/10.1002/1873-3468.13589

Author

Packer, J R ; Hirst, A M ; Droop, A P ; Adamson, R ; Simms, M S ; Mann, V M ; Frame, F M ; O'Connell, D ; Maitland, N J. / Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments. In: FEBS Letters. 2019.

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@article{eca50ea3f2644677829bf31dcc416d98,
title = "Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments",
abstract = "Low Temperature Plasma (LTP) generates reactive oxygen and nitrogen species, causing cell death, similarly to radiation. Radiation resistance results in tumour recurrence, however mechanisms of LTP resistance are unknown. LTP was applied to patient-derived prostate epithelial cells and gene expression assessed. A typical global oxidative response (AP-1 and Nrf2 signalling) was induced, whereas Notch signalling was activated exclusively in progenitor cells. Notch inhibition induced expression of prostatic acid phosphatase (PAP), a marker of prostate epithelial cell differentiation, whilst reducing colony forming ability and preventing tumour formation. Therefore, if LTP is to be progressed as a novel treatment for prostate cancer, combination treatments should be considered in the context of cellular heterogeneity and existence of cell type-specific resistance mechanisms.",
author = "Packer, {J R} and Hirst, {A M} and Droop, {A P} and R Adamson and Simms, {M S} and Mann, {V M} and Frame, {F M} and D O'Connell and Maitland, {N J}",
note = "{\circledC}2019 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.",
year = "2019",
month = "9",
day = "17",
doi = "10.1002/1873-3468.13589",
language = "English",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments

AU - Packer, J R

AU - Hirst, A M

AU - Droop, A P

AU - Adamson, R

AU - Simms, M S

AU - Mann, V M

AU - Frame, F M

AU - O'Connell, D

AU - Maitland, N J

N1 - ©2019 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

PY - 2019/9/17

Y1 - 2019/9/17

N2 - Low Temperature Plasma (LTP) generates reactive oxygen and nitrogen species, causing cell death, similarly to radiation. Radiation resistance results in tumour recurrence, however mechanisms of LTP resistance are unknown. LTP was applied to patient-derived prostate epithelial cells and gene expression assessed. A typical global oxidative response (AP-1 and Nrf2 signalling) was induced, whereas Notch signalling was activated exclusively in progenitor cells. Notch inhibition induced expression of prostatic acid phosphatase (PAP), a marker of prostate epithelial cell differentiation, whilst reducing colony forming ability and preventing tumour formation. Therefore, if LTP is to be progressed as a novel treatment for prostate cancer, combination treatments should be considered in the context of cellular heterogeneity and existence of cell type-specific resistance mechanisms.

AB - Low Temperature Plasma (LTP) generates reactive oxygen and nitrogen species, causing cell death, similarly to radiation. Radiation resistance results in tumour recurrence, however mechanisms of LTP resistance are unknown. LTP was applied to patient-derived prostate epithelial cells and gene expression assessed. A typical global oxidative response (AP-1 and Nrf2 signalling) was induced, whereas Notch signalling was activated exclusively in progenitor cells. Notch inhibition induced expression of prostatic acid phosphatase (PAP), a marker of prostate epithelial cell differentiation, whilst reducing colony forming ability and preventing tumour formation. Therefore, if LTP is to be progressed as a novel treatment for prostate cancer, combination treatments should be considered in the context of cellular heterogeneity and existence of cell type-specific resistance mechanisms.

U2 - 10.1002/1873-3468.13589

DO - 10.1002/1873-3468.13589

M3 - Article

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

ER -