Novel synthetic methodologies for fluorination and perfluoroalkylation

D J  Adams; J H  Clark; P A  Heath; L B  Hansen; V C  Sanders; S J  Tavener

Novel synthetic methodologies for fluorination and perfluoroalkylation

D J Adams, J H Clark, P A Heath, L B Hansen, V C Sanders, S J Tavener

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Nucleophilic routes to selectively fluorinated aromatic compounds starting from cheap and readily available nitroaromatics are reviewed. Me3SiCF3, in conjunction with a fluoride, can be used as either a fluorinating or trifluoromethylating agent, and is capable of both the trifluoromethyldenitration and trifluoromethyldecyanation of an aromatic molecule. Nucleophilic trifluoromethylthiolation can be achieved using thiophosgene and a fluoride. (C) 2000 Elsevier Science S.A. All rights reserved.

Original language	English
Pages (from-to)	187-191
Number of pages	5
Journal	JOURNAL OF FLUORINE CHEMISTRY
Volume	101
Issue number	2
Publication status	Published - Feb 2000

Keywords

fluorination
perfluoroalkylation
fluorodenitration
trifluoromethyltrimethylsilane

Cite this

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title = "Novel synthetic methodologies for fluorination and perfluoroalkylation",

abstract = "Nucleophilic routes to selectively fluorinated aromatic compounds starting from cheap and readily available nitroaromatics are reviewed. Me3SiCF3, in conjunction with a fluoride, can be used as either a fluorinating or trifluoromethylating agent, and is capable of both the trifluoromethyldenitration and trifluoromethyldecyanation of an aromatic molecule. Nucleophilic trifluoromethylthiolation can be achieved using thiophosgene and a fluoride. (C) 2000 Elsevier Science S.A. All rights reserved.",

keywords = "fluorination, perfluoroalkylation, fluorodenitration, trifluoromethyltrimethylsilane",

author = "Adams, {D J} and Clark, {J H} and Heath, {P A} and Hansen, {L B} and Sanders, {V C} and Tavener, {S J}",

year = "2000",

month = feb,

language = "English",

volume = "101",

pages = "187--191",

journal = "JOURNAL OF FLUORINE CHEMISTRY",

issn = "0022-1139",

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TY - JOUR

T1 - Novel synthetic methodologies for fluorination and perfluoroalkylation

AU - Adams, D J

AU - Clark, J H

AU - Heath, P A

AU - Hansen, L B

AU - Sanders, V C

AU - Tavener, S J

PY - 2000/2

Y1 - 2000/2

N2 - Nucleophilic routes to selectively fluorinated aromatic compounds starting from cheap and readily available nitroaromatics are reviewed. Me3SiCF3, in conjunction with a fluoride, can be used as either a fluorinating or trifluoromethylating agent, and is capable of both the trifluoromethyldenitration and trifluoromethyldecyanation of an aromatic molecule. Nucleophilic trifluoromethylthiolation can be achieved using thiophosgene and a fluoride. (C) 2000 Elsevier Science S.A. All rights reserved.

AB - Nucleophilic routes to selectively fluorinated aromatic compounds starting from cheap and readily available nitroaromatics are reviewed. Me3SiCF3, in conjunction with a fluoride, can be used as either a fluorinating or trifluoromethylating agent, and is capable of both the trifluoromethyldenitration and trifluoromethyldecyanation of an aromatic molecule. Nucleophilic trifluoromethylthiolation can be achieved using thiophosgene and a fluoride. (C) 2000 Elsevier Science S.A. All rights reserved.

KW - fluorination

KW - perfluoroalkylation

KW - fluorodenitration

KW - trifluoromethyltrimethylsilane

M3 - Article

SN - 0022-1139

VL - 101

SP - 187

EP - 191

JO - JOURNAL OF FLUORINE CHEMISTRY

JF - JOURNAL OF FLUORINE CHEMISTRY

IS - 2

ER -