By the same authors

From the same journal

Novel synthetic methodologies for fluorination and perfluoroalkylation

Research output: Contribution to journalArticle

Author(s)

  • D J Adams
  • J H Clark
  • P A Heath
  • L B Hansen
  • V C Sanders
  • S J Tavener

Department/unit(s)

Publication details

JournalJOURNAL OF FLUORINE CHEMISTRY
DatePublished - Feb 2000
Issue number2
Volume101
Number of pages5
Pages (from-to)187-191
Original languageEnglish

Abstract

Nucleophilic routes to selectively fluorinated aromatic compounds starting from cheap and readily available nitroaromatics are reviewed. Me3SiCF3, in conjunction with a fluoride, can be used as either a fluorinating or trifluoromethylating agent, and is capable of both the trifluoromethyldenitration and trifluoromethyldecyanation of an aromatic molecule. Nucleophilic trifluoromethylthiolation can be achieved using thiophosgene and a fluoride. (C) 2000 Elsevier Science S.A. All rights reserved.

    Research areas

  • fluorination, perfluoroalkylation, fluorodenitration, trifluoromethyltrimethylsilane

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