Nucleophilic routes to selectively fluorinated aromatics

D J Adams, J H Clark

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Selectively fluorinated aromatic compounds are of interest in many sectors. Of the methodologies used for their formation, halogen exchange is the only industrial rival to the diazonium based routes, Although many compounds can be formed by halogen exchange, the formation of meta-fluorinated species by this route is difficult, One possible method for overcoming this is fluorodenitration, Although traditionally plagued by side reactions, recent reports suggest that, with careful control of the reaction conditions, fluorodenitration could well provide a viable industrial alternative for the formation of selectively fluorinated aromatic compounds.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalChemical Society Reviews
Volume28
Issue number4
Publication statusPublished - Jul 1999

Keywords

  • TETRAMETHYLAMMONIUM FLUORIDE
  • POTASSIUM FLUORIDE
  • EXCHANGE
  • DISPLACEMENT
  • ION
  • HYDROGENDIFLUORIDE
  • FLUORODENITRATION
  • ANHYDRIDE
  • NITRITE

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