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On the structure of motor symptoms of Parkinson's disease

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • Jan Stochl
  • Anne Boomsma
  • Evzen Ruzicka
  • Hana Brozova
  • Petr Blahus

Department/unit(s)

Publication details

JournalMovement disorders : official journal of the Movement Disorder Society
DatePublished - 15 Jul 2008
Issue number9
Volume23
Number of pages6
Pages (from-to)1307-12
Original languageEnglish

Abstract

This study aims to investigate the structure of the motor symptoms of Parkinson's disease (PD), as measured by the Motor Section of the Unified Parkinson's Disease Rating Scale (UPDRS). The dimensionality of the Motor Section of the UPDRS was studied using structural equation modeling. The UPDRS measures were obtained from 405 patients with PD [237 men (39 "off", 170 "on", 28 unknown) and 168 women (21 "off", 140 "on", 7 unknown)]. The ordinal character of UPDRS scores and sample size substantiated the use of robust diagonally weighted least squares model estimation. It was shown that the Motor Section of the UPDRS incorporates five main latent symptom factors (rigidity, tremor, bradykinesia of the extremities, axial/gait bradykinesia, speech/hypomimia) plus two additional factors for laterality, which account for asymmetry of tremor, rigidity and bradykinesia of the extremities. Tremor seems to be an independent symptom factor of PD. Other latent variables are substantially correlated.

Bibliographical note

(c) 2008 Movement Disorder Society.

    Research areas

  • Adult, Aged, Aged, 80 and over, Dyskinesias, Female, Humans, Hypokinesia, Male, Middle Aged, Muscle Rigidity, Neurologic Examination, Parkinson Disease, Tremor

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