One-component gels based on peptidic dendrimers: Dendritic effects on materials properties

C S Love, A R Hirst, V Chechik, D K Smith, I Ashworth, C Brennan

Research output: Contribution to journalArticlepeer-review

Abstract

This paper describes the gelation of symmetric dendrimers based on building blocks constructed from L-lysine. These dendrimers form gel-phase materials in nonpolar organic solvents. The thermal properties and concentration dependence of the gelation. were investigated, and it was found that there was a clear dendritic effect on the behavior of the soft materials formed, with higher generation dendrimers giving rise to more thermally stable gels. Variable temperature H-1 NMR studies indicated that this behavior was probably a consequence of more extensive interdendrimer hydrogen bonding occurring between the peptidic groups in the higher generation dendrimers. The supramolecular aggregates were found to have a fibrillar structure, with the dimensions and alignment of the fibers being dependent on dendritic generation. Circular dichroism measurements confirmed that these fibers possessed chiral organization of the peptidic groups on the supramolecular (nano) scale, assigned as helicity. This paper indicates that dendritic functionalization provides a useful way of tuning gel-phase materials properties, with clear dendritic effects on gel formation being quantified for the first time, hence illustrating the way dendritic functionalization can play a positive role in the formation of highly functional organic materials with desirable properties.

Original languageEnglish
Pages (from-to)6580-6585
Number of pages6
JournalLangmuir
Volume20
Issue number16
DOIs
Publication statusPublished - 3 Aug 2004

Keywords

  • 2-DIRECTIONAL CASCADE MOLECULES
  • SUPRAMOLECULAR ARCHITECTURES
  • ORGANIC LIQUIDS
  • L-LYSINE
  • GELATORS
  • ORGANOGELS
  • CHEMISTRY
  • NANORIBBONS
  • ASSEMBLIES
  • STABILITY

Cite this