One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues

Jianxiong Zhao, Benjamin R. Lichman, John M. Ward, Helen C. Hailes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Chemoenzymatic reaction cascades can provide access to chiral compounds from low-cost starting materials in one pot. Here we describe one-pot asymmetric routes to tetrahydroisoquinoline alkaloids (THIAs) using the Pictet-Spenglerase norcoclaurine synthase (NCS) followed by a cyclisation, to give alkaloids with two new heterocyclic rings. These reactions operated with a high atom economy to generate THIAs in high yields.

Original languageEnglish
Pages (from-to)1323-1326
Number of pages4
JournalChemical Communications
Issue number11
Publication statusPublished - 1 Jan 2018

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©The Royal Society of Chemistry 2018

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