One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

B. R. Lichman; E. D. Lamming; T. Pesnot; J. M. Smith; H. C. Hailes; J. M. Ward

doi:10.1039/c4gc02325k

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

B. R. Lichman, E. D. Lamming, T. Pesnot, J. M. Smith, H. C. Hailes^*, J. M. Ward

^*Corresponding author for this work

Biology

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Abstract

We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and norcoclaurine synthase (NCS) in a one-pot, one-substrate 'triangular' cascade. Employment of up to two C-C bond forming steps allows for the rapid generation of molecular complexity under mild conditions. This journal is

Original language	English
Pages (from-to)	852-855
Number of pages	4
Journal	Green Chemistry
Volume	17
Issue number	2
DOIs	https://doi.org/10.1039/c4gc02325k
Publication status	Published - 1 Feb 2015

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AU - Lamming, E. D.

AU - Pesnot, T.

AU - Smith, J. M.

AU - Hailes, H. C.

AU - Ward, J. M.

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One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

Abstract

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