One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

B. R. Lichman, E. D. Lamming, T. Pesnot, J. M. Smith, H. C. Hailes*, J. M. Ward

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and norcoclaurine synthase (NCS) in a one-pot, one-substrate 'triangular' cascade. Employment of up to two C-C bond forming steps allows for the rapid generation of molecular complexity under mild conditions. This journal is

Original languageEnglish
Pages (from-to)852-855
Number of pages4
JournalGreen Chemistry
Issue number2
Publication statusPublished - 1 Feb 2015

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