Abstract
Model organisms arc vital to our understanding of human muscle biology and disease. The potential of the nematode Caenorhabditis elegans, the fruitfly, Drosophila melanogaster and the zebrafish, Danio rerio, as model genetic organisms for the study of human muscle disease is discussed by examining their muscle biology, muscle genetics and development. The powerful genetic tools available with each organism arc outlined. It is concluded that these organisms have already demonstrated potential in facilitating the study of muscle disease and in screening for therapeutic agents.
Original language | English |
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Title of host publication | SARCOMERE AND SKELETAL MUSCLE DISEASE |
Place of Publication | BERLIN |
Publisher | Springer |
Pages | 192-206 |
Number of pages | 15 |
Publication status | Published - 2008 |
Keywords
- MYOSIN HEAVY-CHAIN
- DYSTROPHIN-GLYCOPROTEIN COMPLEX
- NEMATODE CAENORHABDITIS-ELEGANS
- FISH SPARUS-AURATA
- SKELETAL-MUSCLE
- FLIGHT-MUSCLE
- DROSOPHILA-MELANOGASTER
- TROPONIN-I
- STEM-CELL
- C-ELEGANS