Other Model Organisms for Sarcomeric Muscle Diseases

By the same authors

Binding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle
Katzemich, A., West, R. J. H., Fukuzawa, A., Sweeney, S. T., Gautel, M., Sparrow, J. & Bullard, B., 15 Sep 2015
Article in Journal of Cell Science
Sallimus and the dynamics of sarcomere assembly in Drosophila flight muscles
Orfanos, Z., Leonard, K., Elliott, C., Katzemich, A., Bullard, B. & Sparrow, J., 19 Jun 2015
Article in Journal of Molecular Biology
The function of the M-line protein obscurin in controlling the symmetry of the sarcomere in the flight muscle of Drosophila
Katzemich, A., Kreisköther, N., Alexandrovich, A., Elliott, C., Schöck, F., Leonard, K., Sparrow, J. & Bullard, B., 15 Jul 2012
Article in Journal of Cell Science
In vivo measurement of muscle output in intact Drosophila
Elliott, C. J. H. & Sparrow, J. C., Jan 2012
Article in Methods
Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation
Stenzel, W., Prokop, S., Kress, W., Huppmann, S., Loui, A., Sarioglu, N. M. E., Laing, N. G., Sparrow, J. C., Heppner, F. L. & Goebel, H. H., Aug 2010
Article in Neuromuscular disorders

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Author(s)

John Sparrow
Simon M. Hughes
Laurent Segalat

Department/unit(s)

Biology

Publication details

Title of host publication	SARCOMERE AND SKELETAL MUSCLE DISEASE
Date	Published - 2008
Pages	192-206
Number of pages	15
Publisher	SPRINGER-VERLAG BERLIN
Place of Publication	BERLIN
Original language	English

Abstract

Model organisms arc vital to our understanding of human muscle biology and disease. The potential of the nematode Caenorhabditis elegans, the fruitfly, Drosophila melanogaster and the zebrafish, Danio rerio, as model genetic organisms for the study of human muscle disease is discussed by examining their muscle biology, muscle genetics and development. The powerful genetic tools available with each organism arc outlined. It is concluded that these organisms have already demonstrated potential in facilitating the study of muscle disease and in screening for therapeutic agents.

Research areas

MYOSIN HEAVY-CHAIN, DYSTROPHIN-GLYCOPROTEIN COMPLEX, NEMATODE CAENORHABDITIS-ELEGANS, FISH SPARUS-AURATA, SKELETAL-MUSCLE, FLIGHT-MUSCLE, DROSOPHILA-MELANOGASTER, TROPONIN-I, STEM-CELL, C-ELEGANS

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By the same authors

Binding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle

Sallimus and the dynamics of sarcomere assembly in Drosophila flight muscles

The function of the M-line protein obscurin in controlling the symmetry of the sarcomere in the flight muscle of Drosophila

In vivo measurement of muscle output in intact Drosophila

Fetal akinesia caused by a novel actin filament aggregate myopathy skeletal muscle actin gene (ACTA1) mutation