By the same authors

Other Model Organisms for Sarcomeric Muscle Diseases

Research output: Chapter in Book/Report/Conference proceedingChapter

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Publication details

Title of host publicationSARCOMERE AND SKELETAL MUSCLE DISEASE
DatePublished - 2008
Pages192-206
Number of pages15
PublisherSPRINGER-VERLAG BERLIN
Place of PublicationBERLIN
Original languageEnglish

Abstract

Model organisms arc vital to our understanding of human muscle biology and disease. The potential of the nematode Caenorhabditis elegans, the fruitfly, Drosophila melanogaster and the zebrafish, Danio rerio, as model genetic organisms for the study of human muscle disease is discussed by examining their muscle biology, muscle genetics and development. The powerful genetic tools available with each organism arc outlined. It is concluded that these organisms have already demonstrated potential in facilitating the study of muscle disease and in screening for therapeutic agents.

    Research areas

  • MYOSIN HEAVY-CHAIN, DYSTROPHIN-GLYCOPROTEIN COMPLEX, NEMATODE CAENORHABDITIS-ELEGANS, FISH SPARUS-AURATA, SKELETAL-MUSCLE, FLIGHT-MUSCLE, DROSOPHILA-MELANOGASTER, TROPONIN-I, STEM-CELL, C-ELEGANS

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