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Overlapping Functions of Cdx1, Cdx2, and Cdx4 in the Development of the Amphibian Xenopus tropicalis

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Overlapping Functions of Cdx1, Cdx2, and Cdx4 in the Development of the Amphibian Xenopus tropicalis. / Faas, Laura; Isaacs, Harry V.

In: Developmental Dynamics, Vol. 238, No. 4, 04.2009, p. 835-852.

Research output: Contribution to journalArticlepeer-review

Harvard

Faas, L & Isaacs, HV 2009, 'Overlapping Functions of Cdx1, Cdx2, and Cdx4 in the Development of the Amphibian Xenopus tropicalis', Developmental Dynamics, vol. 238, no. 4, pp. 835-852. https://doi.org/10.1002/dvdy.21901

APA

Faas, L., & Isaacs, H. V. (2009). Overlapping Functions of Cdx1, Cdx2, and Cdx4 in the Development of the Amphibian Xenopus tropicalis. Developmental Dynamics, 238(4), 835-852. https://doi.org/10.1002/dvdy.21901

Vancouver

Faas L, Isaacs HV. Overlapping Functions of Cdx1, Cdx2, and Cdx4 in the Development of the Amphibian Xenopus tropicalis. Developmental Dynamics. 2009 Apr;238(4):835-852. https://doi.org/10.1002/dvdy.21901

Author

Faas, Laura ; Isaacs, Harry V. / Overlapping Functions of Cdx1, Cdx2, and Cdx4 in the Development of the Amphibian Xenopus tropicalis. In: Developmental Dynamics. 2009 ; Vol. 238, No. 4. pp. 835-852.

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@article{c3a81aae385745bf86aca0a50a8deb24,
title = "Overlapping Functions of Cdx1, Cdx2, and Cdx4 in the Development of the Amphibian Xenopus tropicalis",
abstract = "Using Xenopus tropicalis, we present the first analysis of the developmental effects that result from knocking down the function of the three Cdx genes present in the typical vertebrate genome. Knockdowns of individual Cdx genes lead to a similar range of posterior defects; compound Cdx knockdowns result in increasingly severe posterior truncations, accompanied by posterior shifts and reduction of 5' Hox gene expression. We provide evidence that Cdx and Wnt3A genes are components of a positive feedback loop operating in the posterior axis. We show that Cdx function is required during later, but not early stages of development, for correct regional specification of the endoderm and morphogenesis of the gut. Our results support the hypothesis that during amphibian development the overall landscape of Cdx activity in the embryo is more important than the specific function of individual Cdx proteins. Developmental Dynamics 238:835-852, 2009. (C) 2009 Wiley-Liss, Inc.",
keywords = "Cdx, Xenopus, Hox, caudal, mesoderm, endoderm, morphogenesis, wnt, ANTERIOR-POSTERIOR AXIS, CANONICAL WNT PATHWAY, HOX GENE-EXPRESSION, CAUDAL GENES, ANTEROPOSTERIOR SPECIFICATION, INTESTINAL METAPLASIA, EARLY EMBRYOGENESIS, ECTOPIC EXPRESSION, SPEMANNS ORGANIZER, TRANSGENIC MICE",
author = "Laura Faas and Isaacs, {Harry V.}",
note = "Copyright 2009 Wiley-Liss, Inc.",
year = "2009",
month = apr,
doi = "10.1002/dvdy.21901",
language = "English",
volume = "238",
pages = "835--852",
journal = "Developmental Dynamics",
issn = "1058-8388",
number = "4",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Overlapping Functions of Cdx1, Cdx2, and Cdx4 in the Development of the Amphibian Xenopus tropicalis

AU - Faas, Laura

AU - Isaacs, Harry V.

N1 - Copyright 2009 Wiley-Liss, Inc.

PY - 2009/4

Y1 - 2009/4

N2 - Using Xenopus tropicalis, we present the first analysis of the developmental effects that result from knocking down the function of the three Cdx genes present in the typical vertebrate genome. Knockdowns of individual Cdx genes lead to a similar range of posterior defects; compound Cdx knockdowns result in increasingly severe posterior truncations, accompanied by posterior shifts and reduction of 5' Hox gene expression. We provide evidence that Cdx and Wnt3A genes are components of a positive feedback loop operating in the posterior axis. We show that Cdx function is required during later, but not early stages of development, for correct regional specification of the endoderm and morphogenesis of the gut. Our results support the hypothesis that during amphibian development the overall landscape of Cdx activity in the embryo is more important than the specific function of individual Cdx proteins. Developmental Dynamics 238:835-852, 2009. (C) 2009 Wiley-Liss, Inc.

AB - Using Xenopus tropicalis, we present the first analysis of the developmental effects that result from knocking down the function of the three Cdx genes present in the typical vertebrate genome. Knockdowns of individual Cdx genes lead to a similar range of posterior defects; compound Cdx knockdowns result in increasingly severe posterior truncations, accompanied by posterior shifts and reduction of 5' Hox gene expression. We provide evidence that Cdx and Wnt3A genes are components of a positive feedback loop operating in the posterior axis. We show that Cdx function is required during later, but not early stages of development, for correct regional specification of the endoderm and morphogenesis of the gut. Our results support the hypothesis that during amphibian development the overall landscape of Cdx activity in the embryo is more important than the specific function of individual Cdx proteins. Developmental Dynamics 238:835-852, 2009. (C) 2009 Wiley-Liss, Inc.

KW - Cdx

KW - Xenopus

KW - Hox

KW - caudal

KW - mesoderm

KW - endoderm

KW - morphogenesis

KW - wnt

KW - ANTERIOR-POSTERIOR AXIS

KW - CANONICAL WNT PATHWAY

KW - HOX GENE-EXPRESSION

KW - CAUDAL GENES

KW - ANTEROPOSTERIOR SPECIFICATION

KW - INTESTINAL METAPLASIA

KW - EARLY EMBRYOGENESIS

KW - ECTOPIC EXPRESSION

KW - SPEMANNS ORGANIZER

KW - TRANSGENIC MICE

UR - http://www.scopus.com/inward/record.url?scp=63849233073&partnerID=8YFLogxK

U2 - 10.1002/dvdy.21901

DO - 10.1002/dvdy.21901

M3 - Article

C2 - 19301404

VL - 238

SP - 835

EP - 852

JO - Developmental Dynamics

JF - Developmental Dynamics

SN - 1058-8388

IS - 4

ER -