Overview of the CCP4 suite and current developments

Martyn D. Winn, Charles C. Ballard, Kevin D. Cowtan, Eleanor J. Dodson, Paul Emsley, Phil R. Evans, Ronan M. Keegan, Eugene B. Krissinel, Andrew G. W. Leslie, Airlie McCoy, Stuart J. McNicholas, Garib N. Murshudov, Navraj S. Pannu, Elizabeth A. Potterton, Harold R. Powell, Randy J. Read, Alexei Vagin, Keith S. Wilson

Research output: Contribution to journalArticlepeer-review

Abstract

The CCP4 (Collaborative Computational Project, Number 4) software suite is a collection of programs and associated data and software libraries which can be used for macromolecular structure determination by X-ray crystallography. The suite is designed to be flexible, allowing users a number of methods of achieving their aims. The programs are from a wide variety of sources but are connected by a common infrastructure provided by standard file formats, data objects and graphical interfaces. Structure solution by macromolecular crystallography is becoming increasingly automated and the CCP4 suite includes several automation pipelines. After giving a brief description of the evolution of CCP4 over the last 30 years, an overview of the current suite is given. While detailed descriptions are given in the accompanying articles, here it is shown how the individual programs contribute to a complete software package.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalActa Crystallographica. Section D, Biological Crystallography
Volume67
Issue number4
DOIs
Publication statusPublished - Apr 2011

Keywords

  • MOLECULAR-GRAPHICS PROJECT
  • MACROMOLECULAR STRUCTURES
  • PHASE INFORMATION
  • MODEL REFINEMENT
  • CRYSTALLOGRAPHY
  • REPLACEMENT
  • SOFTWARE
  • MOLREP
  • KNOWLEDGE
  • EXAMPLES

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