OXIDATION OF SOME PROCHIRAL 3-SUBSTITUTED CYCLOBUTANONES USING MONOOXYGENASE ENZYMES - A SINGLE-STEP METHOD FOR THE SYNTHESIS OF OPTICALLY ENRICHED 3-SUBSTITUTED GAMMA-LACTONES

R  GAGNON; G  GROGAN; E  GROUSSAIN; S  PEDRAGOSAMOREAU; P F  RICHARDSON; S M  ROBERTS; A J  WILLETTS; V  ALPHAND; J  LEBRETON; R  FURSTOSS

OXIDATION OF SOME PROCHIRAL 3-SUBSTITUTED CYCLOBUTANONES USING MONOOXYGENASE ENZYMES - A SINGLE-STEP METHOD FOR THE SYNTHESIS OF OPTICALLY ENRICHED 3-SUBSTITUTED GAMMA-LACTONES

R GAGNON, G GROGAN, E GROUSSAIN, S PEDRAGOSAMOREAU, P F RICHARDSON, S M ROBERTS, A J WILLETTS, V ALPHAND, J LEBRETON, R FURSTOSS

Chemistry

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Oxidation of the prochiral cyclobutanones 1-5 using Acinetobacter calcoaceticus NCIMB 9871 and Pseudomonas putida NCIMB 10007 monooxygenases (MO1 and MO2) furnishes the corresponding lactones 6-10 in moderate to excellent yield and enantiomeric purity. These enzymes show enantiocomplementarity in all but one case.

Original language	English
Pages (from-to)	2527-2528
Number of pages	2
Journal	Journal of the Chemical Society-Perkin Transactions 1
Issue number	20
Publication status	Published - 21 Oct 1995

Keywords

TRANSFORMATIONS

Cite this

GAGNON, R., GROGAN, G., GROUSSAIN, E., PEDRAGOSAMOREAU, S., RICHARDSON, P. F., ROBERTS, S. M., WILLETTS, A. J., ALPHAND, V., LEBRETON, J., & FURSTOSS, R. (1995). OXIDATION OF SOME PROCHIRAL 3-SUBSTITUTED CYCLOBUTANONES USING MONOOXYGENASE ENZYMES - A SINGLE-STEP METHOD FOR THE SYNTHESIS OF OPTICALLY ENRICHED 3-SUBSTITUTED GAMMA-LACTONES. Journal of the Chemical Society-Perkin Transactions 1, (20), 2527-2528.

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title = "OXIDATION OF SOME PROCHIRAL 3-SUBSTITUTED CYCLOBUTANONES USING MONOOXYGENASE ENZYMES - A SINGLE-STEP METHOD FOR THE SYNTHESIS OF OPTICALLY ENRICHED 3-SUBSTITUTED GAMMA-LACTONES",

abstract = "Oxidation of the prochiral cyclobutanones 1-5 using Acinetobacter calcoaceticus NCIMB 9871 and Pseudomonas putida NCIMB 10007 monooxygenases (MO1 and MO2) furnishes the corresponding lactones 6-10 in moderate to excellent yield and enantiomeric purity. These enzymes show enantiocomplementarity in all but one case.",

keywords = "TRANSFORMATIONS",

author = "R GAGNON and G GROGAN and E GROUSSAIN and S PEDRAGOSAMOREAU and RICHARDSON, {P F} and ROBERTS, {S M} and WILLETTS, {A J} and V ALPHAND and J LEBRETON and R FURSTOSS",

year = "1995",

month = oct,

day = "21",

language = "English",

pages = "2527--2528",

journal = "Journal of the Chemical Society-Perkin Transactions 1",

issn = "0300-922X",

publisher = "Chemical Society",

number = "20",

}

GAGNON, R, GROGAN, G, GROUSSAIN, E, PEDRAGOSAMOREAU, S, RICHARDSON, PF, ROBERTS, SM, WILLETTS, AJ, ALPHAND, V, LEBRETON, J & FURSTOSS, R 1995, 'OXIDATION OF SOME PROCHIRAL 3-SUBSTITUTED CYCLOBUTANONES USING MONOOXYGENASE ENZYMES - A SINGLE-STEP METHOD FOR THE SYNTHESIS OF OPTICALLY ENRICHED 3-SUBSTITUTED GAMMA-LACTONES', Journal of the Chemical Society-Perkin Transactions 1, no. 20, pp. 2527-2528.

OXIDATION OF SOME PROCHIRAL 3-SUBSTITUTED CYCLOBUTANONES USING MONOOXYGENASE ENZYMES - A SINGLE-STEP METHOD FOR THE SYNTHESIS OF OPTICALLY ENRICHED 3-SUBSTITUTED GAMMA-LACTONES. / GAGNON, R ; GROGAN, G ; GROUSSAIN, E et al.
In: Journal of the Chemical Society-Perkin Transactions 1, No. 20, 21.10.1995, p. 2527-2528.

Research output: Contribution to journal › Comment/debate › peer-review

TY - JOUR

T1 - OXIDATION OF SOME PROCHIRAL 3-SUBSTITUTED CYCLOBUTANONES USING MONOOXYGENASE ENZYMES - A SINGLE-STEP METHOD FOR THE SYNTHESIS OF OPTICALLY ENRICHED 3-SUBSTITUTED GAMMA-LACTONES

AU - GAGNON, R

AU - GROGAN, G

AU - GROUSSAIN, E

AU - PEDRAGOSAMOREAU, S

AU - RICHARDSON, P F

AU - ROBERTS, S M

AU - WILLETTS, A J

AU - ALPHAND, V

AU - LEBRETON, J

AU - FURSTOSS, R

PY - 1995/10/21

Y1 - 1995/10/21

N2 - Oxidation of the prochiral cyclobutanones 1-5 using Acinetobacter calcoaceticus NCIMB 9871 and Pseudomonas putida NCIMB 10007 monooxygenases (MO1 and MO2) furnishes the corresponding lactones 6-10 in moderate to excellent yield and enantiomeric purity. These enzymes show enantiocomplementarity in all but one case.

AB - Oxidation of the prochiral cyclobutanones 1-5 using Acinetobacter calcoaceticus NCIMB 9871 and Pseudomonas putida NCIMB 10007 monooxygenases (MO1 and MO2) furnishes the corresponding lactones 6-10 in moderate to excellent yield and enantiomeric purity. These enzymes show enantiocomplementarity in all but one case.

KW - TRANSFORMATIONS

M3 - Comment/debate

SN - 0300-922X

SP - 2527

EP - 2528

JO - Journal of the Chemical Society-Perkin Transactions 1

JF - Journal of the Chemical Society-Perkin Transactions 1

IS - 20

ER -