Oxime Ligation on the Surface of Mesoporous Silica Nanoparticles

Daniel P. Ferris, Paul R. McGonigal, Leah S. Witus, Takatoshi Kawaji, Mohammed M. Algaradah, Ahmed R. Alnajadah, Majed S. Nassar, J. Fraser Stoddart*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented). A versatile surface-functionalization strategy applicable to mesoporous silica nanoparticles, which could potentially serve as drug delivery vehicles, is described that makes use of alkoxyamine tethers on the surface of the nanoparticles. A wide variety of carbonyl compounds can be attached readily to these tethers under the mild conditions of oxime ether formation, simply by incubating the chemically modified mesoporous silica nanoparticles with aldehydes or ketones in water.

Original languageEnglish
Pages (from-to)2146-2149
Number of pages4
JournalOrganic letters
Issue number9
Publication statusPublished - 1 May 2015

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© 2015 American Chemical Society.

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