Palladium-mediated cell-surface labeling

Christopher D. Spicer; Therese Triemer; Benjamin G. Davis

doi:10.1021/ja209352s

Palladium-mediated cell-surface labeling

Christopher D. Spicer, Therese Triemer, Benjamin G. Davis^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Benign C-C bond formation at various sites in cell-surface channels has been achieved through Suzuki-Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.

Original language	English
Pages (from-to)	800-803
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	134
Issue number	2
DOIs	https://doi.org/10.1021/ja209352s
Publication status	Published - 18 Jan 2012

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10.1021/ja209352s

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title = "Palladium-mediated cell-surface labeling",

abstract = "Benign C-C bond formation at various sites in cell-surface channels has been achieved through Suzuki-Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.",

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AU - Triemer, Therese

AU - Davis, Benjamin G.

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N2 - Benign C-C bond formation at various sites in cell-surface channels has been achieved through Suzuki-Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.

AB - Benign C-C bond formation at various sites in cell-surface channels has been achieved through Suzuki-Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.

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JO - Journal of the American Chemical Society

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Palladium-mediated cell-surface labeling

Abstract

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