Projects per year
Abstract
Protein bioconjugation frequently makes use of aldehydes as reactive handles, with methods for their installation being highly valued. Here a new, powerful strategy to unmask a reactive protein aldehyde is presented. A genetically encoded caged glyoxyl aldehyde, situated in solvent-accessible locations, can be rapidly decade through treatment with just one equivalent of allylpalladium(II) chloride dimer at physiological pH. The protein aldehyde can undergo subsequent oxime ligation for site-selective protein modification. Quick yet mild conditions, orthogonality and powerful exposed reactivity make this strategy of great potential in protein modification.
Original language | English |
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Pages (from-to) | 1501-1504 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 54 |
Publication status | Published - 6 Feb 2018 |
Projects
- 2 Finished
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Tandem organocatalysis for the bi-functional modification of proteins
Fascione, M. A. (Principal investigator)
1/11/17 → 31/10/18
Project: Research project (funded) › Research
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Technologies for the Future
Thomas-Oates, J. E. (Principal investigator) & Johnson, S. D. (Co-investigator)
1/04/15 → 31/03/16
Project: Research project (funded) › Research