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Palladium-mediated cell-surface labeling

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JournalJournal of the American Chemical Society
DatePublished - 18 Jan 2012
Issue number2
Volume134
Number of pages4
Pages (from-to)800-803
Original languageEnglish

Abstract

Benign C-C bond formation at various sites in cell-surface channels has been achieved through Suzuki-Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms.

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