Parahydrogen-Induced Hyperpolarization of Gases

TY - JOUR

T1 - Parahydrogen-Induced Hyperpolarization of Gases

AU - Kovtunov, Kirill V.

AU - Koptyug, Igor V.

AU - Fekete, Marianna

AU - Duckett, Simon B.

AU - Theis, Thomas

AU - Joalland, Baptiste

AU - Chekmenev, Eduard Y.

N1 - Funding Information: We thank the following award for funding support: NSF CHE- 1904780 (E.Y.C.), NIH 1R21CA220137 (E.Y.C.), R21EB025313 (T.T.), and 1U01CA202229 (E.Y.C.), DOD CDMRP PRMRP W81XWH-15-1-0271 (E.Y.C.). K.V.K. and I.V.K. thank RSF (grant # 19-13-00047) for the support of MRI studies and RFBR (grant # 19-29-10003 and 17-54-33037) for the support of catalysts synthesis, and Russian Ministry of Science and Higher Education (AAAA-A16-116121510087-5) for the access to NMR/MRI equipment. SBD thanks financial support from the Wellcome Trust (Grants 092506 and 098335), the MRC (MR/M008991/1). T.T. also acknowledges support from the Oak Ridge Associated Universities, Ralph E. Powe Junior Faculty Enhancement Award, the North Carolina Biotechnology Center Translational Research Grant as well as support from the Mallinckrodt foundation. Publisher Copyright: © 2020 Wiley-VCH GmbH

PY - 2020/9/28

Y1 - 2020/9/28

N2 - Imaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization. The level of nuclear spin polarization is typically very low, i.e., one hundred thousandth of the potential maximum at 1.5 T and a physiologically relevant temperature. As a result, MRI typically focusses on imaging highly concentrated tissue water. Hyperpolarization methods transiently increase nuclear spin polarizations up to unity, yielding corresponding gains in MRI signal level of several orders of magnitude that enable the 3D imaging of dilute biomolecules including gases. Parahydrogen-induced polarization is a fast, highly scalable, and low-cost hyperpolarization technique. The focus of this Minireview is to highlight selected advances in the field of parahydrogen-induced polarization for the production of hyperpolarized compounds, which can be potentially employed as inhalable contrast agents.

AB - Imaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization. The level of nuclear spin polarization is typically very low, i.e., one hundred thousandth of the potential maximum at 1.5 T and a physiologically relevant temperature. As a result, MRI typically focusses on imaging highly concentrated tissue water. Hyperpolarization methods transiently increase nuclear spin polarizations up to unity, yielding corresponding gains in MRI signal level of several orders of magnitude that enable the 3D imaging of dilute biomolecules including gases. Parahydrogen-induced polarization is a fast, highly scalable, and low-cost hyperpolarization technique. The focus of this Minireview is to highlight selected advances in the field of parahydrogen-induced polarization for the production of hyperpolarized compounds, which can be potentially employed as inhalable contrast agents.

KW - hyperpolarization

KW - MRI

KW - NMR

KW - parahydrogen

KW - spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=85085978969&partnerID=8YFLogxK

U2 - 10.1002/anie.201915306

DO - 10.1002/anie.201915306

M3 - Review article

C2 - 31972061

AN - SCOPUS:85085978969

VL - 59

SP - 17788

EP - 17797

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 41

ER -