Parahydrogen-induced polarization of amino acids

Andrey Pravdivtsev, Gerd Buntkowsky, Simon B. Duckett, Igor Koptyug, Jan-Bernd Hövener

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Nuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spins has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid-state NMR and metabolic imaging in vivo). Parahydrogen (pH2) offers a fast and cost-efficient way to achieve hyperpolarization, and the last decade has seen extensive advances including the synthesis of new tracers, catalysts, and transfer methods. The portfolio of hyperpolarized molecules now includes amino acids, which are of great interest for many applications. Here, we review the current literature and developments for the hyperpolarization of amino acids and peptides.
Original languageEnglish
Number of pages13
JournalAngewandte Chemie International Edition
Early online date13 Aug 2021
Publication statusE-pub ahead of print - 13 Aug 2021

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© 2021 The Authors.

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