@article{bd6c08dcf4fc419896c70167624cefde,
title = "Parallel adaptation of rabbit populations to myxoma virus",
abstract = "In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.",
author = "Alves, {Joel M.} and Miguel Carneiro and Cheng, {Jade Y.} and Matos, {Ana Lemos de} and Rahman, {Masmudur M.} and Liisa Loog and Campos, {Paula F.} and Nathan Wales and Anders Eriksson and Andrea Manica and Tanja Strive and Graham, {Stephen C.} and Sandra Afonso and Bell, {Diana J.} and Laura Belmont and Day, {Jonathan P.} and Fuller, {Susan J.} and St{\'e}phane Marchandeau and Palmer, {William J.} and Guillaume Queney and Surridge, {Alison K.} and Vieira, {Filipe G.} and Grant McFadden and Rasmus Nielsen and Gilbert, {M. Thomas P.} and Esteves, {Pedro J.} and Nuno Ferrand and Jiggins, {Francis M.}",
note = "This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details. ",
year = "2019",
month = feb,
day = "14",
doi = "10.1126/science.aau7285",
language = "English",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
}