Parameters of the attenuated schistosome vaccine evaluated in the olive baboon

T.M. Kariuki; I.O. Farah; D.S. Yole; J.M. Mwenda; G.J. Van Dam; A.M. Deelder; P.S. Coulson; R.A. Wilson

doi:10.1128/IAI.72.9.5526-5529.2004

Parameters of the attenuated schistosome vaccine evaluated in the olive baboon

T.M. Kariuki, I.O. Farah, D.S. Yole, J.M. Mwenda, G.J. Van Dam, A.M. Deelder, P.S. Coulson, R.A. Wilson

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.

Original language	English
Pages (from-to)	5526-5529
Number of pages	4
Journal	Infection and Immunity
Volume	72
Issue number	9
DOIs	https://doi.org/10.1128/IAI.72.9.5526-5529.2004
Publication status	Published - Sep 2004

Bibliographical note

Keywords

IRRADIATED CERCARIA VACCINE
CIRCULATING ANODIC ANTIGEN
PAPIO-ANUBIS
MONOCLONAL-ANTIBODIES
PROTECTIVE IMMUNITY
MANSONI
RESPONSES

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Cite this

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title = "Parameters of the attenuated schistosome vaccine evaluated in the olive baboon",

abstract = "Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.",

keywords = "IRRADIATED CERCARIA VACCINE, CIRCULATING ANODIC ANTIGEN, PAPIO-ANUBIS, MONOCLONAL-ANTIBODIES, PROTECTIVE IMMUNITY, MANSONI, RESPONSES",

author = "T.M. Kariuki and I.O. Farah and D.S. Yole and J.M. Mwenda and {Van Dam}, G.J. and A.M. Deelder and P.S. Coulson and R.A. Wilson",

note = "Copyright {\textcopyright} 2004, American Society for Microbiology",

year = "2004",

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doi = "10.1128/IAI.72.9.5526-5529.2004",

language = "English",

volume = "72",

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journal = "Infection and Immunity",

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TY - JOUR

T1 - Parameters of the attenuated schistosome vaccine evaluated in the olive baboon

AU - Kariuki, T.M.

AU - Farah, I.O.

AU - Yole, D.S.

AU - Mwenda, J.M.

AU - Van Dam, G.J.

AU - Deelder, A.M.

AU - Coulson, P.S.

AU - Wilson, R.A.

PY - 2004/9

Y1 - 2004/9

N2 - Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.

AB - Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.

KW - IRRADIATED CERCARIA VACCINE

KW - CIRCULATING ANODIC ANTIGEN

KW - PAPIO-ANUBIS

KW - MONOCLONAL-ANTIBODIES

KW - PROTECTIVE IMMUNITY

KW - MANSONI

KW - RESPONSES

U2 - 10.1128/IAI.72.9.5526-5529.2004

DO - 10.1128/IAI.72.9.5526-5529.2004

M3 - Article

VL - 72

SP - 5526

EP - 5529

JO - Infection and Immunity

JF - Infection and Immunity

SN - 1098-5522

IS - 9

ER -