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Parameters of the attenuated schistosome vaccine evaluated in the olive baboon

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Author(s)

  • T.M. Kariuki
  • I.O. Farah
  • D.S. Yole
  • J.M. Mwenda
  • G.J. Van Dam
  • A.M. Deelder
  • P.S. Coulson
  • R.A. Wilson

Department/unit(s)

Publication details

JournalInfection and Immunity
DatePublished - Sep 2004
Issue number9
Volume72
Number of pages4
Pages (from-to)5526-5529
Original languageEnglish

Abstract

Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.

Bibliographical note

Copyright © 2004, American Society for Microbiology

    Research areas

  • IRRADIATED CERCARIA VACCINE, CIRCULATING ANODIC ANTIGEN, PAPIO-ANUBIS, MONOCLONAL-ANTIBODIES, PROTECTIVE IMMUNITY, MANSONI, RESPONSES

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