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Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: findings from the Childhood Leukaemia International Consortium (CLIC)

Research output: Contribution to journalArticle

Author(s)

  • Madar Talibov
  • Ann Olsson
  • Helen Bailey
  • Friederike Erdmann
  • Catherine Metayer
  • Corrado Magnani
  • Eleni Petridou
  • Anssi Auvinen
  • Logan Spector
  • Jacqueline Clavel
  • Eve Roman
  • John Dockerty
  • Atte Nikkilä
  • Olli Lohi
  • Alice Kang
  • Theodora Psaltopoulou
  • Lucia Miligi
  • Javier Vila
  • Elisabeth Cardis
  • Joachim Schüz

Department/unit(s)

Publication details

JournalOccupational and Environmental Medicine
DateAccepted/In press - 30 Jun 2019
DateE-pub ahead of print - 29 Jul 2019
DatePublished (current) - Oct 2019
Issue number10
Volume76
Number of pages8
Pages (from-to)746-753
Early online date29/07/19
Original languageEnglish

Abstract

OBJECTIVES: Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium.

METHODS: We pooled 11 case-control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses.

RESULTS: ORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (µT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 µT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses.

CONCLUSIONS: In this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia.

Bibliographical note

© Author(s) (or their employer(s)) 2019.

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