Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium

Catherine Metayer; Eleni Petridou; Juan Manuel Mejía Aranguré; Eve Roman; Joachim Schüz; Corrado Magnani; Ana Maria Mora; Beth A. Mueller; Maria S.Pombo De Oliveira; John D. Dockerty; Kathryn McCauley; Tracy Lightfoot; Emmanouel Hatzipantelis; Jérémie Rudant; Janet Flores-Lujano; Peter Kaatsch; Lucia Miligi; Catharina Wesseling; David R. Doody; Maria Moschovi; Laurent Orsi; Stefano Mattioli; Steve Selvin; Alice Y. Kang; Jacqueline Clavel; Juan Carlos Nuñez-Enriquez; Elva Jiménez-Hernández; Rogelio Paredes-Aguilera

doi:10.1093/aje/kww018

Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium

Catherine Metayer^*, Eleni Petridou, Juan Manuel Mejía Aranguré, Eve Roman, Joachim Schüz, Corrado Magnani, Ana Maria Mora, Beth A. Mueller, Maria S.Pombo De Oliveira, John D. Dockerty, Kathryn McCauley, Tracy Lightfoot, Emmanouel Hatzipantelis, Jérémie Rudant, Janet Flores-Lujano, Peter Kaatsch, Lucia Miligi, Catharina Wesseling, David R. Doody, Maria MoschoviLaurent Orsi, Stefano Mattioli, Steve Selvin, Alice Y. Kang, Jacqueline Clavel, Juan Carlos Nuñez-Enriquez, Elva Jiménez-Hernández, Rogelio Paredes-Aguilera

^*Corresponding author for this work

Health Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age <15 years and 13,169 controls. We conducted pooled analyses of CLIC studies, as well as meta-analyses of CLIC and non-CLIC studies. Overall, maternal smoking before, during, or after pregnancy was not associated with childhood AML; there was a suggestion, however, that smoking during pregnancy was associated with an increased risk in Hispanics (odds ratio = 2.08, 95% confidence interval (CI): 1.20, 3.61) but not in other ethnic groups. By contrast, the odds ratios for paternal lifetime smoking were 1.34 (95% CI: 1.11, 1.62) and 1.18 (95% CI: 0.92, 1.51) in pooled and meta-analyses, respectively. Overall, increased risks from 1.2- to 1.3-fold were observed for pre- and postnatal smoking (P < 0.05), with higher risks reported for heavy smokers. Associations with paternal smoking varied by histological type. Our analyses suggest an association between paternal smoking and childhood AML. The association with maternal smoking appears limited to Hispanic children, raising questions about ethnic differences in tobacco-related exposures and biological mechanisms, as well as study-specific biases.

Original language	English
Pages (from-to)	261-273
Number of pages	13
Journal	American Journal of Epidemiology
Volume	184
Issue number	4
DOIs	https://doi.org/10.1093/aje/kww018
Publication status	Published - 3 Aug 2016

Bibliographical note

© The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

Keywords

acute myeloid leukemia
childhood cancer
international collaboration
parental smoking

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tobacco smoking
© The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
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Metayer, C., Petridou, E., Aranguré, J. M. M., Roman, E., Schüz, J., Magnani, C., Mora, A. M., Mueller, B. A., De Oliveira, M. S. P., Dockerty, J. D., McCauley, K., Lightfoot, T., Hatzipantelis, E., Rudant, J., Flores-Lujano, J., Kaatsch, P., Miligi, L., Wesseling, C., Doody, D. R., ... Paredes-Aguilera, R. (2016). Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium. American Journal of Epidemiology, 184(4), 261-273. https://doi.org/10.1093/aje/kww018

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title = "Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium",

abstract = "The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age <15 years and 13,169 controls. We conducted pooled analyses of CLIC studies, as well as meta-analyses of CLIC and non-CLIC studies. Overall, maternal smoking before, during, or after pregnancy was not associated with childhood AML; there was a suggestion, however, that smoking during pregnancy was associated with an increased risk in Hispanics (odds ratio = 2.08, 95% confidence interval (CI): 1.20, 3.61) but not in other ethnic groups. By contrast, the odds ratios for paternal lifetime smoking were 1.34 (95% CI: 1.11, 1.62) and 1.18 (95% CI: 0.92, 1.51) in pooled and meta-analyses, respectively. Overall, increased risks from 1.2- to 1.3-fold were observed for pre- and postnatal smoking (P < 0.05), with higher risks reported for heavy smokers. Associations with paternal smoking varied by histological type. Our analyses suggest an association between paternal smoking and childhood AML. The association with maternal smoking appears limited to Hispanic children, raising questions about ethnic differences in tobacco-related exposures and biological mechanisms, as well as study-specific biases.",

keywords = "acute myeloid leukemia, childhood cancer, international collaboration, parental smoking",

author = "Catherine Metayer and Eleni Petridou and Arangur{\'e}, {Juan Manuel Mej{\'i}a} and Eve Roman and Joachim Sch{\"u}z and Corrado Magnani and Mora, {Ana Maria} and Mueller, {Beth A.} and {De Oliveira}, {Maria S.Pombo} and Dockerty, {John D.} and Kathryn McCauley and Tracy Lightfoot and Emmanouel Hatzipantelis and J{\'e}r{\'e}mie Rudant and Janet Flores-Lujano and Peter Kaatsch and Lucia Miligi and Catharina Wesseling and Doody, {David R.} and Maria Moschovi and Laurent Orsi and Stefano Mattioli and Steve Selvin and Kang, {Alice Y.} and Jacqueline Clavel and Nu{\~n}ez-Enriquez, {Juan Carlos} and Elva Jim{\'e}nez-Hern{\'a}ndez and Rogelio Paredes-Aguilera",

note = "{\textcopyright} The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an author-produced version of the published paper. Uploaded in accordance with the publisher{\textquoteright}s self-archiving policy. Further copying may not be permitted; contact the publisher for details.",

year = "2016",

month = aug,

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doi = "10.1093/aje/kww018",

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Metayer, C, Petridou, E, Aranguré, JMM, Roman, E, Schüz, J, Magnani, C, Mora, AM, Mueller, BA, De Oliveira, MSP, Dockerty, JD, McCauley, K, Lightfoot, T, Hatzipantelis, E, Rudant, J, Flores-Lujano, J, Kaatsch, P, Miligi, L, Wesseling, C, Doody, DR, Moschovi, M, Orsi, L, Mattioli, S, Selvin, S, Kang, AY, Clavel, J, Nuñez-Enriquez, JC, Jiménez-Hernández, E & Paredes-Aguilera, R 2016, 'Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium', American Journal of Epidemiology, vol. 184, no. 4, pp. 261-273. https://doi.org/10.1093/aje/kww018

TY - JOUR

T1 - Parental Tobacco Smoking and Acute Myeloid Leukemia

T2 - The Childhood Leukemia International Consortium

AU - Metayer, Catherine

AU - Petridou, Eleni

AU - Aranguré, Juan Manuel Mejía

AU - Roman, Eve

AU - Schüz, Joachim

AU - Magnani, Corrado

AU - Mora, Ana Maria

AU - Mueller, Beth A.

AU - De Oliveira, Maria S.Pombo

AU - Dockerty, John D.

AU - McCauley, Kathryn

AU - Lightfoot, Tracy

AU - Hatzipantelis, Emmanouel

AU - Rudant, Jérémie

AU - Flores-Lujano, Janet

AU - Kaatsch, Peter

AU - Miligi, Lucia

AU - Wesseling, Catharina

AU - Doody, David R.

AU - Moschovi, Maria

AU - Orsi, Laurent

AU - Mattioli, Stefano

AU - Selvin, Steve

AU - Kang, Alice Y.

AU - Clavel, Jacqueline

AU - Nuñez-Enriquez, Juan Carlos

AU - Jiménez-Hernández, Elva

AU - Paredes-Aguilera, Rogelio

N1 - © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

PY - 2016/8/3

Y1 - 2016/8/3

N2 - The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age <15 years and 13,169 controls. We conducted pooled analyses of CLIC studies, as well as meta-analyses of CLIC and non-CLIC studies. Overall, maternal smoking before, during, or after pregnancy was not associated with childhood AML; there was a suggestion, however, that smoking during pregnancy was associated with an increased risk in Hispanics (odds ratio = 2.08, 95% confidence interval (CI): 1.20, 3.61) but not in other ethnic groups. By contrast, the odds ratios for paternal lifetime smoking were 1.34 (95% CI: 1.11, 1.62) and 1.18 (95% CI: 0.92, 1.51) in pooled and meta-analyses, respectively. Overall, increased risks from 1.2- to 1.3-fold were observed for pre- and postnatal smoking (P < 0.05), with higher risks reported for heavy smokers. Associations with paternal smoking varied by histological type. Our analyses suggest an association between paternal smoking and childhood AML. The association with maternal smoking appears limited to Hispanic children, raising questions about ethnic differences in tobacco-related exposures and biological mechanisms, as well as study-specific biases.

AB - The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age <15 years and 13,169 controls. We conducted pooled analyses of CLIC studies, as well as meta-analyses of CLIC and non-CLIC studies. Overall, maternal smoking before, during, or after pregnancy was not associated with childhood AML; there was a suggestion, however, that smoking during pregnancy was associated with an increased risk in Hispanics (odds ratio = 2.08, 95% confidence interval (CI): 1.20, 3.61) but not in other ethnic groups. By contrast, the odds ratios for paternal lifetime smoking were 1.34 (95% CI: 1.11, 1.62) and 1.18 (95% CI: 0.92, 1.51) in pooled and meta-analyses, respectively. Overall, increased risks from 1.2- to 1.3-fold were observed for pre- and postnatal smoking (P < 0.05), with higher risks reported for heavy smokers. Associations with paternal smoking varied by histological type. Our analyses suggest an association between paternal smoking and childhood AML. The association with maternal smoking appears limited to Hispanic children, raising questions about ethnic differences in tobacco-related exposures and biological mechanisms, as well as study-specific biases.

KW - acute myeloid leukemia

KW - childhood cancer

KW - international collaboration

KW - parental smoking

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U2 - 10.1093/aje/kww018

DO - 10.1093/aje/kww018

M3 - Review article

AN - SCOPUS:84983294342

SN - 0002-9262

VL - 184

SP - 261

EP - 273

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 4

ER -

Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium

Abstract

Bibliographical note

Keywords

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