The dual function and role of iron(0) pentacarbonyl [Fe(CO)5] has been identified in gaseous CO-free carbonylative Suzuki-Miyaura cross-couplings, in which Fe(CO)5supplied COin situ, leading to the propagation of catalytically active Pd-Fe nanoparticles. Compared with typical carbonylative reaction conditions, CO gas (at high pressures), specialised exogenous ligands and inert reaction conditions were avoided. Our developed reaction conditions are mild, do not require specialised CO high pressure equipment, and exhibit wide functional group tolerance, giving a library of biaryl ketones in good yields.
Bibliographical noteFunding Information:
This work was supported by the grant from the National Natural Science Foundation of China (21371112 and 21446014), the 111 Project (B14041), the Fundamental Funds Research for the Central Universities (No. GK201501005, GK201503029, and 2016CSY002), the grant from the Fundamental Doctoral Fund of Ministry of Education of China (20120202120005), and the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R33). I. J. S. F. is grateful to the Royal Society for University Research Fellowship (2004-12). We thank Syngenta and the University of York for the iCASE funding and studentship to T. J. B. We also acknowledge the Leverhulme Trust for funding, enabling us to initiate this research (W. Z., I. J. S. F., and J. M. L.).
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