Pd-catalysed cross-couplings for the pharmaceutical sector and a move to cutting-edge c-h bond functionalization: Is palladium simply too precious?

Ian J S Fairlamb*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


The case is made for Pd being a critical metal catalyst for a variety of key pharmaceutical sector reactions. There is a need to make such processes more sustainable, e.g. through catalyst recycling, use of lower catalyst loadings and deployment in sustainable C-H activation reactions that avoid high molecular weight waste side-products. Understanding the role played by higher order Pd species (nanoparticles and clusters) is essential in the future. These and related aspects are discussed within this chapter.

Original languageEnglish
Title of host publicationGreen and Sustainable Medicinal Chemistry
Subtitle of host publicationMethods, Tools and Strategies for the 21st Century Pharmaceutical Industry
PublisherThe Royal Society of Chemistry
Number of pages11
ISBN (Electronic)978-1-78262-747-0
ISBN (Print)978-1-78262-467-7
Publication statusPublished - 2016

Publication series

NameRSC Green Chemistry
ISSN (Print)17577039
ISSN (Electronic)17577047

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