Pd-catalysed cross-couplings for the pharmaceutical sector and a move to cutting-edge c-h bond functionalization: Is palladium simply too precious?

Ian J S Fairlamb

doi:10.1039/9781782625940-00129

Pd-catalysed cross-couplings for the pharmaceutical sector and a move to cutting-edge c-h bond functionalization: Is palladium simply too precious?

Ian J S Fairlamb^*

^*Corresponding author for this work

Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The case is made for Pd being a critical metal catalyst for a variety of key pharmaceutical sector reactions. There is a need to make such processes more sustainable, e.g. through catalyst recycling, use of lower catalyst loadings and deployment in sustainable C-H activation reactions that avoid high molecular weight waste side-products. Understanding the role played by higher order Pd species (nanoparticles and clusters) is essential in the future. These and related aspects are discussed within this chapter.

Original language	English
Title of host publication	Green and Sustainable Medicinal Chemistry
Subtitle of host publication	Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry
Publisher	The Royal Society of Chemistry
Pages	129-139
Number of pages	11
ISBN (Electronic)	978-1-78262-747-0
ISBN (Print)	978-1-78262-467-7
DOIs	https://doi.org/10.1039/9781782625940-00129
Publication status	Published - 2016

Publication series

Name	RSC Green Chemistry
Number	46
Volume	2016-January
ISSN (Print)	17577039
ISSN (Electronic)	17577047

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10.1039/9781782625940-00129

Cite this

Fairlamb, I. J. S. (2016). Pd-catalysed cross-couplings for the pharmaceutical sector and a move to cutting-edge c-h bond functionalization: Is palladium simply too precious? In Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry (pp. 129-139). [Chapter 11] (RSC Green Chemistry; Vol. 2016-January, No. 46). The Royal Society of Chemistry. https://doi.org/10.1039/9781782625940-00129

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abstract = "The case is made for Pd being a critical metal catalyst for a variety of key pharmaceutical sector reactions. There is a need to make such processes more sustainable, e.g. through catalyst recycling, use of lower catalyst loadings and deployment in sustainable C-H activation reactions that avoid high molecular weight waste side-products. Understanding the role played by higher order Pd species (nanoparticles and clusters) is essential in the future. These and related aspects are discussed within this chapter.",

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Fairlamb, IJS 2016, Pd-catalysed cross-couplings for the pharmaceutical sector and a move to cutting-edge c-h bond functionalization: Is palladium simply too precious? in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry., Chapter 11, RSC Green Chemistry, no. 46, vol. 2016-January, The Royal Society of Chemistry, pp. 129-139. https://doi.org/10.1039/9781782625940-00129

Pd-catalysed cross-couplings for the pharmaceutical sector and a move to cutting-edge c-h bond functionalization : Is palladium simply too precious? / Fairlamb, Ian J S.

Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry. The Royal Society of Chemistry, 2016. p. 129-139 Chapter 11 (RSC Green Chemistry; Vol. 2016-January, No. 46).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Fairlamb IJS. Pd-catalysed cross-couplings for the pharmaceutical sector and a move to cutting-edge c-h bond functionalization: Is palladium simply too precious? In Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry. The Royal Society of Chemistry. 2016. p. 129-139. Chapter 11. (RSC Green Chemistry; 46). doi: 10.1039/9781782625940-00129

Pd-catalysed cross-couplings for the pharmaceutical sector and a move to cutting-edge c-h bond functionalization: Is palladium simply too precious?

Abstract

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Chem21: Chemical Manufacturing Methods for the 21st Century Pharmaceutical Industries

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Pd-catalysed cross-couplings for the pharmaceutical sector and a move to cutting-edge c-h bond functionalization: Is palladium simply too precious?

Abstract

Publication series

Access to Document

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Chem21: Chemical Manufacturing Methods for the 21st Century Pharmaceutical Industries

Cite this