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From the same journal

Pd-catalysed intramolecular regioselective arylation of 2-pyrones, pyridones, coumarins and quinolones by C-H bond functionalization

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JournalTetrahedron
DatePublished - 7 Oct 2014
Issue number40
Volume70
Number of pages8
Pages (from-to)7120-7127
Original languageEnglish

Abstract

The intramolecular arylation of 2-pyrones, 2-pyridones, coumarins and quinolones is reported using Pd precatalyst sources without added phosphine ligands. The excellent yields and convenient reagents enables the formation of various analogues containing these moieties, and access to potential biologically active candidates. Stoichiometric studies were carried out to provide an insight into the oxidation addition step. A switch in regioselectivity, together with a hydrodebromination process, was observed in the case of a 3-bromo-2-pyrone.

    Research areas

  • Palladium, Cross-Coupling, Catalysis, Organic Chemistry, Synthetic Chemistry, MECHANISM

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