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From the same journal

Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N-8-citryl-spermidine and its N-1-(3,4-dihydroxybenzoyl) derivative

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JournalChemical Communications
DatePublished - 14 Sep 2008
Issue number34
Number of pages3
Pages (from-to)4034-4036
Original languageEnglish

Abstract

The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophore petrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N-1-(3,4-dihydroxbenzoyl)-spermidine, with N-8-citryl-spermidine or N-1-(3,4-dihydroxbenzoyl)-N-8-citryl-spermidine, suggesting that N-1-(3,4-dihydroxbenzoyl)-spermidine is very unlikely to be a significant intermediate in petrobactin biosynthesis, contrary to previous suggestions.

    Research areas

  • SIDEROPHORE BIOSYNTHESIS, MYCOBACTERIUM-TUBERCULOSIS, BACILLUS-ANTHRACIS

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