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Phase-locked Auditory Stimulation of Theta Oscillations during Rapid Eye Movement Sleep

Research output: Contribution to journalArticlepeer-review

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Phase-locked Auditory Stimulation of Theta Oscillations during Rapid Eye Movement Sleep. / Harrington, Marcus Oliver; Ashton, Jennifer; Ngo, Hong-Viet; Cairney, Scott Ashley.

In: Sleep, 25.10.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Harrington, MO, Ashton, J, Ngo, H-V & Cairney, SA 2020, 'Phase-locked Auditory Stimulation of Theta Oscillations during Rapid Eye Movement Sleep', Sleep.

APA

Harrington, M. O., Ashton, J., Ngo, H-V., & Cairney, S. A. (Accepted/In press). Phase-locked Auditory Stimulation of Theta Oscillations during Rapid Eye Movement Sleep. Sleep.

Vancouver

Harrington MO, Ashton J, Ngo H-V, Cairney SA. Phase-locked Auditory Stimulation of Theta Oscillations during Rapid Eye Movement Sleep. Sleep. 2020 Oct 25.

Author

Harrington, Marcus Oliver ; Ashton, Jennifer ; Ngo, Hong-Viet ; Cairney, Scott Ashley. / Phase-locked Auditory Stimulation of Theta Oscillations during Rapid Eye Movement Sleep. In: Sleep. 2020.

Bibtex - Download

@article{eb50f063ad7342bdb52e1f06a84b8d57,
title = "Phase-locked Auditory Stimulation of Theta Oscillations during Rapid Eye Movement Sleep",
abstract = "Auditory closed-loop stimulation is a non-invasive technique that has been widely used to augment slow oscillations during non-rapid eye movement sleep. Based on the principles of closed-loop stimulation, we developed a novel protocol for manipulating theta activity (3-7 Hz) in rapid eye movement (REM) sleep. Sixteen healthy young adults were studied in two overnight conditions: Stimulation and Sham. In the Stimulation condition, 1 s of 5 Hz amplitude-modulated white noise was delivered upon detection of two supra-threshold theta cycles throughout REM sleep. In the Sham condition, corresponding time points were marked but no stimulation was delivered. Auditory stimulation entrained EEG activity to 5 Hz and evoked a brief (~0.5 s) increase in theta power. Interestingly, this initial theta surge was immediately followed by a prolonged (~3 s) period of theta suppression. Stimulation also induced a prolonged (~2 s) increase in beta power. Our results provide the first demonstration that the REM sleep theta rhythm can be manipulated in a targeted manner via auditory stimulation. Accordingly, auditory stimulation might offer a fruitful avenue for investigating REM sleep electrophysiology and its relationship to behaviour. ",
author = "Harrington, {Marcus Oliver} and Jennifer Ashton and Hong-Viet Ngo and Cairney, {Scott Ashley}",
year = "2020",
month = oct,
day = "25",
language = "English",
journal = "Sleep",
issn = "0161-8105",
publisher = "Oxford University Press",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Phase-locked Auditory Stimulation of Theta Oscillations during Rapid Eye Movement Sleep

AU - Harrington, Marcus Oliver

AU - Ashton, Jennifer

AU - Ngo, Hong-Viet

AU - Cairney, Scott Ashley

PY - 2020/10/25

Y1 - 2020/10/25

N2 - Auditory closed-loop stimulation is a non-invasive technique that has been widely used to augment slow oscillations during non-rapid eye movement sleep. Based on the principles of closed-loop stimulation, we developed a novel protocol for manipulating theta activity (3-7 Hz) in rapid eye movement (REM) sleep. Sixteen healthy young adults were studied in two overnight conditions: Stimulation and Sham. In the Stimulation condition, 1 s of 5 Hz amplitude-modulated white noise was delivered upon detection of two supra-threshold theta cycles throughout REM sleep. In the Sham condition, corresponding time points were marked but no stimulation was delivered. Auditory stimulation entrained EEG activity to 5 Hz and evoked a brief (~0.5 s) increase in theta power. Interestingly, this initial theta surge was immediately followed by a prolonged (~3 s) period of theta suppression. Stimulation also induced a prolonged (~2 s) increase in beta power. Our results provide the first demonstration that the REM sleep theta rhythm can be manipulated in a targeted manner via auditory stimulation. Accordingly, auditory stimulation might offer a fruitful avenue for investigating REM sleep electrophysiology and its relationship to behaviour.

AB - Auditory closed-loop stimulation is a non-invasive technique that has been widely used to augment slow oscillations during non-rapid eye movement sleep. Based on the principles of closed-loop stimulation, we developed a novel protocol for manipulating theta activity (3-7 Hz) in rapid eye movement (REM) sleep. Sixteen healthy young adults were studied in two overnight conditions: Stimulation and Sham. In the Stimulation condition, 1 s of 5 Hz amplitude-modulated white noise was delivered upon detection of two supra-threshold theta cycles throughout REM sleep. In the Sham condition, corresponding time points were marked but no stimulation was delivered. Auditory stimulation entrained EEG activity to 5 Hz and evoked a brief (~0.5 s) increase in theta power. Interestingly, this initial theta surge was immediately followed by a prolonged (~3 s) period of theta suppression. Stimulation also induced a prolonged (~2 s) increase in beta power. Our results provide the first demonstration that the REM sleep theta rhythm can be manipulated in a targeted manner via auditory stimulation. Accordingly, auditory stimulation might offer a fruitful avenue for investigating REM sleep electrophysiology and its relationship to behaviour.

M3 - Article

JO - Sleep

JF - Sleep

SN - 0161-8105

ER -