Addition of diethyl phosphite or diethyl thiophosphite to enol ethers, in the presence of a radical initiator, results in the regioselective synthesis of organophosphonate or phosphonothioate derivatives, respectively, under mild conditions. This method can be applied to the stereoselective formation of substituted tetrahydrofurans and tetrahydropyrans, on cyclisation of vinyl ethers bearing unsaturated side chains. (C) 2004 Elsevier Ltd. All rights reserved.
|Number of pages||4|
|Publication status||Published - 21 Jun 2004|
- phosphorus compounds
- radicals and radical reactions
- EFFICIENT SYNTHESIS
- TETRONASIN M139603