Research output: Contribution to journal › Article › peer-review
Rh cyclopropane paper author accepted version
3.57 MB, Word document
Journal | Organic and Biomolecular Chemistry |
---|---|
Date | Accepted/In press - 9 Aug 2016 |
Date | E-pub ahead of print - 23 Aug 2016 |
Date | Published (current) - 26 Sep 2016 |
Issue number | 38 |
Volume | 14 |
Number of pages | 18 |
Pages (from-to) | 8971-8988 |
Early online date | 23/08/16 |
Original language | English |
Phosphorylated cyclopropanes, generated via the Rh(ii)-catalysed intramolecular cyclopropanation of α-(diethoxyphosphoryl)acetates, have been found to be useful precursors in the synthesis of α-alkylidene-γ-butyrolactones. These cyclopropyl intermediates undergo regioselective reductive ring-opening and subsequent Horner-Wadsworth-Emmons olefination to complete the synthesis. Total syntheses of (±)-savinin and (±)-gadain, as well as the first total synthesis of (±)-peperomin E, are all described using this method.
© Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
Find related publications, people, projects, datasets and more using interactive charts.