Photoactivated functionizable tetracarbonyl phenylpyridine manganese(I) complexes as CO-releasing molecules: a direct Suzuki–Miyaura cross-coupling on a thermally-stable CO-RM

Jonathan S. Ward, Joshua T W Bray, Benjamin J. Aucott, Conrad Wagner, Natalie E. Pridmore, Adrian C. Whitwood, James W B Moir, Jason M. Lynam, Ian J S Fairlamb

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A new class of carbon monoxide-releasing molecules (CO-RMs) are reported based on a previously known tetracarbonyl phenylpyridine manganese(I) motif. A pre-functionalized CO-RM undergoes a direct Pd-catalysed Suzuki–Miyaura cross-coupling with phenylboronic acid to give a π-extended three-ring CO-RM. Cross-coupling conditions were modified to allow coupling of a morpholine-containing boronic acid on to a CO-RM, introducing drug-like functionality. An LED system was used to facilitate controlled CO-release. Irradiation using an LED (400 nm or 365 nm) gives rise to faster CO-release, with lower overall input power than traditional use of a TLC lamp (365 nm), as measured by an assay based on the conversion of deoxymyoglobin to carbonmonoxymyoglobin.

Original languageEnglish
Pages (from-to)5044-5051
Number of pages8
Issue number31
Early online date5 Oct 2016
Publication statusPublished - 2 Nov 2016

Bibliographical note

© 2016, John Wiley & Sons, Inc. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.


  • Carbon monoxide
  • Cross-coupling
  • Manganese
  • Photochemistry

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