Photochemical alkylation of glycine leading to phenylalanines

H S  Knowles; K  Hunt; A F  Parsons

Photochemical alkylation of glycine leading to phenylalanines

H S Knowles, K Hunt, A F Parsons

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

UV photolysis of protected glycines in the presence of di-tert-butyl peroxide, benzophenone and substituted toluenes is shown to lead to selective alkylation at the a-position. Phenylalanines are isolated in yields of generally > 50% (based on recovered starting material). (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	7121-7124
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	36
Publication status	Published - 2 Sept 2000

Keywords

radicals and radical reactions
amino acids and derivatives
photochemistry
alkylation
ALPHA-AMINO-ACIDS
PHOTOALKYLATION
DERIVATIVES
RADICALS

Cite this

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title = "Photochemical alkylation of glycine leading to phenylalanines",

abstract = "UV photolysis of protected glycines in the presence of di-tert-butyl peroxide, benzophenone and substituted toluenes is shown to lead to selective alkylation at the a-position. Phenylalanines are isolated in yields of generally > 50% (based on recovered starting material). (C) 2000 Elsevier Science Ltd. All rights reserved.",

keywords = "radicals and radical reactions, amino acids and derivatives, photochemistry, alkylation, ALPHA-AMINO-ACIDS, PHOTOALKYLATION, DERIVATIVES, RADICALS",

author = "Knowles, {H S} and K Hunt and Parsons, {A F}",

year = "2000",

month = sep,

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language = "English",

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journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Photochemical alkylation of glycine leading to phenylalanines

AU - Knowles, H S

AU - Hunt, K

AU - Parsons, A F

PY - 2000/9/2

Y1 - 2000/9/2

N2 - UV photolysis of protected glycines in the presence of di-tert-butyl peroxide, benzophenone and substituted toluenes is shown to lead to selective alkylation at the a-position. Phenylalanines are isolated in yields of generally > 50% (based on recovered starting material). (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - UV photolysis of protected glycines in the presence of di-tert-butyl peroxide, benzophenone and substituted toluenes is shown to lead to selective alkylation at the a-position. Phenylalanines are isolated in yields of generally > 50% (based on recovered starting material). (C) 2000 Elsevier Science Ltd. All rights reserved.

KW - radicals and radical reactions

KW - amino acids and derivatives

KW - photochemistry

KW - alkylation

KW - ALPHA-AMINO-ACIDS

KW - PHOTOALKYLATION

KW - DERIVATIVES

KW - RADICALS

M3 - Article

SN - 0040-4039

VL - 41

SP - 7121

EP - 7124

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 36

ER -