Photochemical Methods for Peptide Macrocylization

Laetitia Raynal; Nicholas C Rose; James R Donald; Christopher Spicer

doi:10.1002/chem.202003779

Photochemical Methods for Peptide Macrocylization

Laetitia Raynal, Nicholas C Rose, James R Donald, Christopher Spicer

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Photochemical reactions have been the subject of renewed interest over the last two decades, leading to the development of many new diverse and powerful chemical transformations. More recently, these developments have been expanded to enable the photochemical macrocylization of peptides and small proteins. These constructs benefit from increased stability, structural rigidity, and biological potency over their linear counterparts, providing opportunities for improved therapeutic agents. In this review, we provide an overview of both the established and emerging methods for photochemical peptide macrocyclization, highlighting both the limitations and opportunities for further innovation in the field.

Original language	English
Journal	Chemistry : A European Journal
DOIs	https://doi.org/10.1002/chem.202003779
Publication status	E-pub ahead of print - 11 Sep 2020

Bibliographical note

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10.1002/chem.202003779Licence: CC BY

chem.202003779
© 2020, The Author(s)
Final published version, 2.44 MBLicence: CC BY

Cite this

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title = "Photochemical Methods for Peptide Macrocylization",

abstract = "Photochemical reactions have been the subject of renewed interest over the last two decades, leading to the development of many new diverse and powerful chemical transformations. More recently, these developments have been expanded to enable the photochemical macrocylization of peptides and small proteins. These constructs benefit from increased stability, structural rigidity, and biological potency over their linear counterparts, providing opportunities for improved therapeutic agents. In this review, we provide an overview of both the established and emerging methods for photochemical peptide macrocyclization, highlighting both the limitations and opportunities for further innovation in the field.",

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AB - Photochemical reactions have been the subject of renewed interest over the last two decades, leading to the development of many new diverse and powerful chemical transformations. More recently, these developments have been expanded to enable the photochemical macrocylization of peptides and small proteins. These constructs benefit from increased stability, structural rigidity, and biological potency over their linear counterparts, providing opportunities for improved therapeutic agents. In this review, we provide an overview of both the established and emerging methods for photochemical peptide macrocyclization, highlighting both the limitations and opportunities for further innovation in the field.

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