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Photochemical Methods for Peptide Macrocylization

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JournalChemistry : A European Journal
DateE-pub ahead of print - 11 Sep 2020
Original languageEnglish

Abstract

Photochemical reactions have been the subject of renewed interest over the last two decades, leading to the development of many new diverse and powerful chemical transformations. More recently, these developments have been expanded to enable the photochemical macrocylization of peptides and small proteins. These constructs benefit from increased stability, structural rigidity, and biological potency over their linear counterparts, providing opportunities for improved therapeutic agents. In this review, we provide an overview of both the established and emerging methods for photochemical peptide macrocyclization, highlighting both the limitations and opportunities for further innovation in the field.

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© 2020, The Author(s).

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