Plasma micronutrient concentrations are associated with inflammatory cytokine levels among Mexican women with greater abdominal fat and higher leptin levels

Kurt Zane Long, Olga P Garcia, Gerardo Zavala, Maria del Carmen Caamano, Luis M Salgado, Jorge L Rosado

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Associations between micronutrient status and inflammatory cytokine responses were evaluated in a cross-sectional study of 580 women from rural Mexico who differed in abdominal fat mass (AFM) and leptin levels. Women's AFM (%) was determined using DEXA. Concentrations of IL-6, TNF-α, leptin, Zn, vitamins A, C, and E were determined in fasting blood samples. Ordered logistic regression models evaluated associations between categorized cytokine levels and micronutrients concentrations stratified by quartiles of abdominal fat and leptin. Higher plasma Zn was associated with reduced IL-6 levels among women in the 3rd quartile of AFM (OR=0.21, 95% CI 0.08?0.6, P=0.03) and reduced TNF-α levels among women in the 4th quartile (OR=0.30, 95%CI 0.11?0.76, p=0.02). Higher vitamin E concentrations were associated with increased IL-6 and TNF-α levels among women in the 4th AFM quartile (OR=1.43, 95% CI 1.06?1.93, p=0.01; OR=1.71, 95%CI 1.16?2.55, p
Original languageEnglish
Pages (from-to)595.12-595.12
JournalThe FASEB Journal
Issue numberS1
Publication statusPublished - 2011


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