Plasmid-mediated horizontal gene transfer is a coevolutionary process

Research output: Contribution to journalLiterature reviewpeer-review


Conjugative plasmids are key agents of horizontal gene transfer (HGT) that accelerate bacterial adaptation by vectoring ecologically important traits between strains and species. However, although many conjugative plasmids carry beneficial traits, all plasmids exert physiological costs-of-carriage on bacteria. The existence of conjugative plasmids, therefore, presents a paradox because non-beneficial plasmids should be lost to purifying selection, whereas beneficial genes carried on plasmids should be integrated into the bacterial chromosome. Several ecological solutions to the paradox have been proposed, but none account for co-adaptation of bacteria and conjugative plasmids. Drawing upon evidence from experimental evolution, we argue that HGT via conjugation can only be fully understood in a coevolutionary framework.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalTrends in microbiology
Issue number6
Publication statusPublished - Jun 2012

Bibliographical note

©2012, Elsevier Ltd. This is an author produced version of a paper published in Trends in Microbiology. Uploaded in accordance with the publisher's self-archiving policy

Cite this