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Plastic Scintillator-Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography Radiopharmaceuticals

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JournalChemistry - A European Journal
DateE-pub ahead of print - 13 Jul 2018
DatePublished (current) - 20 Aug 2018
Issue number52
Volume24
Number of pages5
Pages (from-to)13749-13753
Early online date13/07/18
Original languageEnglish

Abstract

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide, [18F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.

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© 2018, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

    Research areas

  • liquid chromatography, microfluidics, plastic scintillator, positron emission tomography, radiopharmaceuticals, silicon photomultiplier

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