Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes

TY - JOUR

T1 - Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes

AU - Barski, Artem

AU - Chepelev, Iouri

AU - Liko, Dritan

AU - Cuddapah, Suresh

AU - Fleming, Alastair B

AU - Birch, Joanna

AU - Cui, Kairong

AU - White, Robert J

AU - Zhao, Keji

PY - 2010/5

Y1 - 2010/5

N2 - Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin landscape of Pol III-transcribed genes resembles that of Pol II templates in many ways, although there are also clear differences. Our analysis also uncovered an entirely unexpected phenomenon: namely, that Pol II is present at the majority of genomic loci that are bound by Pol III.

AB - Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin landscape of Pol III-transcribed genes resembles that of Pol II templates in many ways, although there are also clear differences. Our analysis also uncovered an entirely unexpected phenomenon: namely, that Pol II is present at the majority of genomic loci that are bound by Pol III.

UR - http://www.scopus.com/inward/record.url?scp=77951956458&partnerID=8YFLogxK

U2 - 10.1038/nsmb.1806

DO - 10.1038/nsmb.1806

M3 - Article

C2 - 20418881

SN - 1545-9993

VL - 17

SP - 629

EP - 634

JO - Nature Structural & Molecular Biology

JF - Nature Structural & Molecular Biology

IS - 5

ER -