Post kala-azar dermal leishmaniasis: an unresolved mystery

Debanjan Mukhopadhyay; Jane E. Dalton; Paul M. Kaye; Mitali Chatterjee

doi:10.1016/j.pt.2013.12.004

Post kala-azar dermal leishmaniasis: an unresolved mystery

Debanjan Mukhopadhyay, Jane E. Dalton, Paul M. Kaye, Mitali Chatterjee

Research output: Contribution to journal › Article › peer-review

Abstract

Post kala-azar dermal leishmaniasis (PKDL), a cutaneous sequela of visceral leishmaniasis (VL), develops in some patients alongside but more commonly after apparent cure from VL. In view of the pivotal role of PKDL patients in the transmission of VL, here we review clinical, epidemiological, parasitological, and immunological perspectives of this disease, focusing on five hypotheses to explain the development of PKDL: (i) the role of antimonial drugs; (ii) UV-induced skin damage; (iii) reinfection; (iv) organ specific failure of memory T cell responses; and (v) genetic susceptibility of the host. This review will enable researchers and clinicians to explore the unresolved mystery of PKDL and provide a framework for future application of 'omic' approaches for the control and eventual elimination of VL.

Original language	English
Pages (from-to)	65-74
Number of pages	10
Journal	Trends in parasitology
Volume	30
Issue number	2
Early online date	2 Jan 2014
DOIs	https://doi.org/10.1016/j.pt.2013.12.004
Publication status	Published - Feb 2014

Bibliographical note

Keywords

Antimony
Post kala-azar dermal leishmaniasis (PKDL)
UV light
Vitamin D
Regulatory T cells

Access to Document

10.1016/j.pt.2013.12.004

Cite this

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title = "Post kala-azar dermal leishmaniasis: an unresolved mystery",

abstract = "Post kala-azar dermal leishmaniasis (PKDL), a cutaneous sequela of visceral leishmaniasis (VL), develops in some patients alongside but more commonly after apparent cure from VL. In view of the pivotal role of PKDL patients in the transmission of VL, here we review clinical, epidemiological, parasitological, and immunological perspectives of this disease, focusing on five hypotheses to explain the development of PKDL: (i) the role of antimonial drugs; (ii) UV-induced skin damage; (iii) reinfection; (iv) organ specific failure of memory T cell responses; and (v) genetic susceptibility of the host. This review will enable researchers and clinicians to explore the unresolved mystery of PKDL and provide a framework for future application of 'omic' approaches for the control and eventual elimination of VL.",

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AU - Dalton, Jane E.

AU - Kaye, Paul M.

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AB - Post kala-azar dermal leishmaniasis (PKDL), a cutaneous sequela of visceral leishmaniasis (VL), develops in some patients alongside but more commonly after apparent cure from VL. In view of the pivotal role of PKDL patients in the transmission of VL, here we review clinical, epidemiological, parasitological, and immunological perspectives of this disease, focusing on five hypotheses to explain the development of PKDL: (i) the role of antimonial drugs; (ii) UV-induced skin damage; (iii) reinfection; (iv) organ specific failure of memory T cell responses; and (v) genetic susceptibility of the host. This review will enable researchers and clinicians to explore the unresolved mystery of PKDL and provide a framework for future application of 'omic' approaches for the control and eventual elimination of VL.

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