Practical Considerations and Challenges When Conducting an Individual Participant Data (IPD) Meta-Analysis

Sarah J Nevitt, Catrin Tudur Smith

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter provides a broad overview of the use of individual participant (sometimes referred to as patient) data (IPD ) within meta-analyses, the associated advantages of using IPD in meta-analysis compared to aggregate data, and when IPD should be used in meta-analysis.This chapter also outlines the steps of conducting an IPD meta-analysis, with practical guidance relating to requesting and obtaining IPD for meta-analysis. Challenges that can be associated with conducting an IPD meta-analysis are also discussed, including consideration of availability bias, when a subset of the relevant IPD is not available for meta-analysis.

Original languageEnglish
Title of host publicationMeta-Research
Subtitle of host publicationMethods and Protocols
Number of pages16
ISBN (Electronic)978-1-0716-1566-9
ISBN (Print)978-1-0716-1565-2
Publication statusPublished - 23 Sept 2021

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
ISSN (Print)1064-3745

Bibliographical note

© 2022. Springer Science+Business Media, LLC, part of Springer Nature.


  • Bias
  • Data Analysis
  • Humans
  • Meta-Analysis as Topic

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