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Precise microdissection of human prostate cancers reveals genotypic heterogeneity

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JournalCancer research
DatePublished - 1 Jan 1998
Issue number1
Volume58
Number of pages6
Pages (from-to)23-28
Original languageEnglish

Abstract

To determine the incidence of genetic heterogeneity in primary prostate cancer, we have microdissected 125 tumor and mesenchymal foci from IS patient biopsies and analyzed the DNA for loss of heterozygosity using PCR microsatellite markers, In 100% of patients with genetic lesions on chromosome 8p, there was evidence for intra-tumoral genetic heterogeneity. There was also a low but significant incidence of loss of heterozygosity in mesenchymal tissue, Our results show that phenotypically similar tumor foci can have different genotypes and provide evidence for the multifocality of tumor development in the prostate.

    Research areas

  • COMPARATIVE GENOMIC HYBRIDIZATION, TUMOR-SUPPRESSOR GENE, ALLELIC LOSS, CHROMOSOME 8P, BONE FIBROBLASTS, GROWTH-INVIVO, DELETION, CARCINOMA, LOCI, HETEROZYGOSITY

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