Predicting Alcohol Use from Genome-Wide Polygenic Scores, Environmental Factors, and Their Interactions in Young Adulthood

TY - JOUR

T1 - Predicting Alcohol Use from Genome-Wide Polygenic Scores, Environmental Factors, and Their Interactions in Young Adulthood

AU - Kandaswamy, Radhika

AU - Allegrini, Andrea

AU - Nancarrow, Alexandra F.

AU - Cave, Sophie Nicole

AU - Plomin, Robert

AU - Von Stumm, Sophie

N1 - Funding Information: Source of Funding and Conflicts of Interest: This study was supported by the European Foundation for Alcohol Research (grant EA1816), the Jacobs Foundation, and the Nuffield Foundation (grant EDO/44110). TEDS is supported by a program grant from the UK Medical Research Council (grant G0901245 and previously G0500079), with additional support from the US National Institutes of Health (grants HD044454 and HD059215). We gratefully acknowledge the ongoing contribution of the TEDS participants and their families. The authors declare no conflict of interest. Publisher Copyright: © Lippincott Williams & Wilkins.

PY - 2022

Y1 - 2022

N2 - Objective Alcohol use during emerging adulthood is associated with adverse life outcomes, but its risk factors are not well known. Here, we predicted alcohol use in 3153 young adults aged 22 years from a) genome-wide polygenic scores (GPS) based on genome-wide association studies for the target phenotypes number of drinks per week and Alcohol Use Disorders Identification Test scores, b) 30 environmental factors, and c) their interactions (i.e., G × E effects). Methods Data were collected from 1994 to 2018 as a part of the UK Twins Early Development Study. Results GPS accounted for up to 1.9% of the variance in alcohol use (i.e., Alcohol Use Disorders Identification Test score), whereas the 30 measures of environmental factors together accounted for 21.1%. The 30 GPS by environment interactions did not explain any additional variance, and none of the interaction terms exceeded the significance threshold after correcting for multiple testing. Conclusions GPS and some environmental factors significantly predicted alcohol use in young adulthood, but we observed no GPS by environment interactions in our study.

AB - Objective Alcohol use during emerging adulthood is associated with adverse life outcomes, but its risk factors are not well known. Here, we predicted alcohol use in 3153 young adults aged 22 years from a) genome-wide polygenic scores (GPS) based on genome-wide association studies for the target phenotypes number of drinks per week and Alcohol Use Disorders Identification Test scores, b) 30 environmental factors, and c) their interactions (i.e., G × E effects). Methods Data were collected from 1994 to 2018 as a part of the UK Twins Early Development Study. Results GPS accounted for up to 1.9% of the variance in alcohol use (i.e., Alcohol Use Disorders Identification Test score), whereas the 30 measures of environmental factors together accounted for 21.1%. The 30 GPS by environment interactions did not explain any additional variance, and none of the interaction terms exceeded the significance threshold after correcting for multiple testing. Conclusions GPS and some environmental factors significantly predicted alcohol use in young adulthood, but we observed no GPS by environment interactions in our study.

KW - alcohol use

KW - gene by environment interaction

KW - polygenic scores

KW - Twins Early Development Study

KW - young adulthood

UR - http://www.scopus.com/inward/record.url?scp=85124496938&partnerID=8YFLogxK

U2 - 10.1097/PSY.0000000000001005

DO - 10.1097/PSY.0000000000001005

M3 - Article

C2 - 34469941

AN - SCOPUS:85124496938

SN - 0033-3174

VL - 84

SP - 244

EP - 250

JO - Psychosomatic medicine

JF - Psychosomatic medicine

IS - 2

ER -