Prefrontal cortex and basal ganglia control access to working memory

Fiona McNab, Torkel Klingberg

Research output: Contribution to journalArticlepeer-review

Abstract

Our capacity to store information in working memory might be determined by the degree to which only relevant information is remembered. The question remains as to how this selection of relevant items to be remembered is accomplished. Here we show that activity in the prefrontal cortex and basal ganglia preceded the filtering of irrelevant information and that activity, particularly in the globus pallidus, predicted the extent to which only relevant information is stored. The preceding frontal and basal ganglia activity were also associated with inter-individual differences in working memory capacity. These findings reveal a mechanism by which frontal and basal ganglia activity exerts attentional control over access to working memory storage in the parietal cortex in humans, and makes an important contribution to inter-individual differences in working memory capacity.

Original languageEnglish
Pages (from-to)103-7
Number of pages5
JournalNature neuroscience
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Adult
  • Basal Ganglia
  • Brain Mapping
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Memory, Short-Term
  • Neuropsychological Tests
  • Oxygen
  • Photic Stimulation
  • Prefrontal Cortex
  • Psychomotor Performance

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