PREPARATION AND APPLICATIONS OF 2-IODO-5-LITHIOTHIOPHENE - SYNTHESIS OF 8,11-THIOLEUKOTRIENE B-3

P T  DESOUSA; R J K  TAYLOR

PREPARATION AND APPLICATIONS OF 2-IODO-5-LITHIOTHIOPHENE - SYNTHESIS OF 8,11-THIOLEUKOTRIENE B-3

Chemistry

Research output: Contribution to journal › Letter › peer-review

Abstract

The title reagent, prepared by lithiation of 2-iodothiophene using lithium diisopropylamide, reacts with a range of electrophiles; the resulting 5-substituted 2-iodothiophenes undergo efficient Sonogashira alkyne coupling reactions, thereby providing an efficient route to 5-substituted 2-(1-alkynyl)-thiophenes and derivatives. Preliminary details of the scope of this sequence are described as is its application to the synthesis of 8,11-thioleukotriene B3 lithium salt.

Original language	English
Pages (from-to)	755-757
Number of pages	3
Journal	Synlett
Issue number	12
Publication status	Published - Dec 1990

Keywords

DERIVATIVES

Cite this

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title = "PREPARATION AND APPLICATIONS OF 2-IODO-5-LITHIOTHIOPHENE - SYNTHESIS OF 8,11-THIOLEUKOTRIENE B-3",

abstract = "The title reagent, prepared by lithiation of 2-iodothiophene using lithium diisopropylamide, reacts with a range of electrophiles; the resulting 5-substituted 2-iodothiophenes undergo efficient Sonogashira alkyne coupling reactions, thereby providing an efficient route to 5-substituted 2-(1-alkynyl)-thiophenes and derivatives. Preliminary details of the scope of this sequence are described as is its application to the synthesis of 8,11-thioleukotriene B3 lithium salt.",

keywords = "DERIVATIVES",

author = "DESOUSA, {P T} and TAYLOR, {R J K}",

year = "1990",

month = dec,

language = "English",

pages = "755--757",

journal = "Synlett",

issn = "1437-2096",

publisher = "Georg Thieme Verlag",

number = "12",

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T1 - PREPARATION AND APPLICATIONS OF 2-IODO-5-LITHIOTHIOPHENE - SYNTHESIS OF 8,11-THIOLEUKOTRIENE B-3

AU - DESOUSA, P T

AU - TAYLOR, R J K

PY - 1990/12

Y1 - 1990/12

N2 - The title reagent, prepared by lithiation of 2-iodothiophene using lithium diisopropylamide, reacts with a range of electrophiles; the resulting 5-substituted 2-iodothiophenes undergo efficient Sonogashira alkyne coupling reactions, thereby providing an efficient route to 5-substituted 2-(1-alkynyl)-thiophenes and derivatives. Preliminary details of the scope of this sequence are described as is its application to the synthesis of 8,11-thioleukotriene B3 lithium salt.

AB - The title reagent, prepared by lithiation of 2-iodothiophene using lithium diisopropylamide, reacts with a range of electrophiles; the resulting 5-substituted 2-iodothiophenes undergo efficient Sonogashira alkyne coupling reactions, thereby providing an efficient route to 5-substituted 2-(1-alkynyl)-thiophenes and derivatives. Preliminary details of the scope of this sequence are described as is its application to the synthesis of 8,11-thioleukotriene B3 lithium salt.

KW - DERIVATIVES

M3 - Letter

SN - 1437-2096

SP - 755

EP - 757

JO - Synlett

JF - Synlett

IS - 12

ER -