By the same authors

From the same journal

PREPARATION AND APPLICATIONS OF 2-IODO-5-LITHIOTHIOPHENE - SYNTHESIS OF 8,11-THIOLEUKOTRIENE B-3

Research output: Contribution to journalLetter

Author(s)

Department/unit(s)

Publication details

JournalSynlett
DatePublished - Dec 1990
Issue number12
Number of pages3
Pages (from-to)755-757
Original languageEnglish

Abstract

The title reagent, prepared by lithiation of 2-iodothiophene using lithium diisopropylamide, reacts with a range of electrophiles; the resulting 5-substituted 2-iodothiophenes undergo efficient Sonogashira alkyne coupling reactions, thereby providing an efficient route to 5-substituted 2-(1-alkynyl)-thiophenes and derivatives. Preliminary details of the scope of this sequence are described as is its application to the synthesis of 8,11-thioleukotriene B3 lithium salt.

    Research areas

  • DERIVATIVES

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations